Vitamin B6 Helps DHA Work Properly

A new study restricted vitamin B6 intake for 28 days in healthy adult men and women, creating a slight deficiency. Doing so lowered the DHA Docosahexaenoic acid Essential omega 3 fatty acid integral to the health of all cell membranes, nerve and brain function. Must be gotten through the diet via cold water oceanic fish or some very limited plant sources or taken as a supplement. content in cell membranes. This study shows that vitamin B6 is needed to help DHA Docosahexaenoic acid Essential omega 3 fatty acid integral to the health of all cell membranes, nerve and brain function. Must be gotten through the diet via cold water oceanic fish or some very limited plant sources or taken as a supplement. get where it needs to go; and even a slight deficiency can cause problems.

B vitamins are essential for many aspects of human metabolism, especially energy production and memory. DHA Docosahexaenoic acid Essential omega 3 fatty acid integral to the health of all cell membranes, nerve and brain function. Must be gotten through the diet via cold water oceanic fish or some very limited plant sources or taken as a supplement. is also one of the most important nutrients for memory, but it must get built into brain cell membranes before it can really help out. Vitamin B6 is likely to help.

Since DHA Docosahexaenoic acid Essential omega 3 fatty acid integral to the health of all cell membranes, nerve and brain function. Must be gotten through the diet via cold water oceanic fish or some very limited plant sources or taken as a supplement. in the membranes of cells in the circulatory system is important for cardiovascular health, researchers concluded there could be “elevated risk of cardiovascular disease in vitamin B6 insufficiency.”

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Lower vitamin D could increase risk of dying, especially for frail, older adults

ScienceDaily (July 26, 2012) — A new study concludes that among older adults -- especially those who are frail -- low levels of vitamin D can mean a much greater risk of death.

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The randomized, nationally representative study found that older adults with low vitamin D levels had a 30 percent greater risk of death than people who had higher levels.

Overall, people who were frail had more than double the risk of death than those who were not frail. Frail adults with low levels of vitamin D tripled their risk of death over people who were not frail and who had higher levels of vitamin D.

"What this really means is that it is important to assess vitamin D levels in older adults, and especially among people who are frail," said lead author Ellen Smit of Oregon State University.

Smit said past studies have separately associated frailty and low vitamin D with a greater mortality risk, but this is the first to look at the combined effect. This study, published online in the European Journal of Clinical Nutrition, examined more than 4,300 adults older than 60 using data from the Third National Health and Nutrition Examination Survey.

"Older adults need to be screened for vitamin D," said Smit, who is a nutritional epidemiologist at OSU's College of Public Health and Human Sciences. Her research is focused on diet, metabolism, and physical activity in relation to both chronic disease and HIV infection.

"As you age, there is an increased risk of melanoma, but older adults should try and get more activity in the sunshine," she said. "Our study suggests that there is an opportunity for intervention with those who are in the pre-frail group, but could live longer, more independent lives if they get proper nutrition and exercise."

Frailty is when a person experiences a decrease in physical functioning characterized by at least three of the following five criteria: muscle weakness, slow walking, exhaustion, low physical activity, and unintentional weight loss. People are considered "pre-frail" when they have one or two of the five criteria.

Because of the cross-sectional nature of the survey, researchers could not determine if low vitamin D contributed to frailty, or whether frail people became vitamin D deficient because of health problems. However, Smit said the longitudinal analysis on death showed it may not matter which came first.

"If you have both, it may not really matter which came first because you are worse off and at greater risk of dying than other older people who are frail and who don't have low vitamin D," she said. "This is an important finding because we already know there is a biological basis for this. Vitamin D impacts muscle function and bones, so it makes sense that it plays a big role in frailty."

The study divided people into four groups. The low group had levels less than 50 nanograms per milliliter; the highest group had vitamin D of 84 or higher. In general, those who had lower vitamin D levels were more likely to be frail.

About 70 percent of Americans, and up to a billion people worldwide, have insufficient levels of vitamin D. And during the winter months in northern climates, it can be difficult to get enough just from the sun. OSU's Linus Pauling Institute recommends adults take 2,000 IU of supplemental vitamin D daily. The current federal guidelines are 600 IU for most adults, and 800 for those older than 70.

"We want the older population to be able to live as independent for as long as possible, and those who are frail have a number of health problems as they age," Smit said. "A balanced diet including good sources of vitamin D like milk and fish, and being physically active outdoors, will go a long way in helping older adults to stay independent and healthy for longer."

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Vitamin E may lower liver cancer risk

ScienceDaily (July 18, 2012) — High consumption of vitamin E either from diet or vitamin supplements may lower the risk of liver cancer, according to a study published July 17 in the Journal of the National Cancer Institute.

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Vitamin E is a fat-soluble vitamin which is considered an antioxidant and numerous experimental studies have suggested that vitamin E may prevent DNA damage.

Liver cancer is the third most common cause of cancer mortality in the world, the fifth most common cancer found in men and the seventh most common in women. Approximately 85 percent of liver cancers occur in developing nations, with 54 percent in China alone.

To determine the relationship between vitamin E intake and liver cancer risk, Wei Zhang, M.D., MPH., Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, and colleagues analyzed data from a total of 132,837 individuals in China who were enrolled in the Shanghai Women’s Health Study (SWHS) from 1997-2000 or the Shanghai Men’s Health Study (SMHS) from 2002-2006, two population-based cohort studies jointly conducted by the Shanghai Cancer Institute and Vanderbilt University.

Using validated food-frequency questionnaires, the researchers conducted in-person interviews to gather data on study participants’ dietary habits. Participants were asked how often they ate some of the most commonly consumed foods in urban Shanghai and whether they took vitamin supplements.

The investigators then compared liver cancer risk among participants who had high intake of vitamin E with those who had low intake.

The analysis included 267 liver cancer patients (118 women and 149 men) who were diagnosed between two years after study enrollment and an average of 10.9 (SWHS) or 5.5 (SMHS) years of follow-up. Vitamin E intake from diet and vitamin E supplement use were both associated with a lower risk of liver cancer. This association was consistent among participants with and without self-reported liver disease or a family history of liver cancer.

“We found a clear, inverse dose-response relation between vitamin E intake and liver cancer risk,” the authors write, noting a small difference between men and women in the risk estimate, which is likely attributable to fewer liver cancer cases having occurred among male participants due to the shorter follow-up period.

“Overall, the take home message is that high intake of vitamin E either from diet or supplements was related to lower risk of liver cancer in middle-aged or older people from China,” said Xiao Ou Shu, M.D., Ph.D., professor of Medicine at the Vanderbilt Epidemiology Center.

Conversely, participants who had the highest vitamin C intake from supplements and who had a family history of liver cancer or self-reported liver disease were more likely to develop liver cancer. There was no link to liver cancer among participants who had the highest levels of vitamin C or other vitamins from food.

Other investigators involved with the study included Honglan Li, M.D., M.Ph., Jing Gao, M.D., Yong-Bing Xiang, M.D., M.Ph., and Yu-Tang Gao, M.D., Shanghai Cancer Institute; Gong Yang, M.D., MPH, Hui Cai, M.D., Ph.D., and Wei Zheng, M.D., Ph.D., Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center; and Bu-Tian Ji, M.D., Dr.PH, National Cancer Institute.

Funding for the study was supported by grants from the National Cancer Institute, a division of the National Institutes of Health (R37 CA070867 and R01 CA082729), the State Key Project Specialized for Infectious Diseases of China (2008ZX10002-015 and 2012ZX10002008-002), and a training grant from the Fogarty International Center (D43 TW008313).

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Low vitamin B6 related to inflammatory Conditions in adults in the United States

Accumulated inflammation and wear and tear are the principal markers of the decline in health.  Many of us take a variety of nutrients to help reduce inflammation and repair of our body.  A new study highlights the fact that we should not forget basic nutrition as a key element of our efforts to anti-inflammatory drugs.  The researchers found that low levels of biologically active B6 (pyridoxal-5-phosphate) had the largest amount of inflammation.

The researchers are interested in this subject, because previous research had linked low B6 to a variety of inflammatory diseases, including cardiovascular disease, rheumatoid arthritis, inflammatory bowel disease and diabetes.

The researchers investigated the levels of blood of the B6 with 13 different inflammatory markers in 2 229 adults, with the average age of 62.  The relationship between a lack of B6 and an increase in inflammation was clear as Crystal.

A vitamin is called vitamin because it cannot be made by your body to something else.  You must consume vitamins in your diet or take as supplements.  The best form of vitamin B6 for supplementation is the biologically active form, pyridoxal-5-phosphate.  Cheap B6, pyridoxine HCL, called requires that your body a gift of energy for her to make it active, and some of the by-products of this metabolic process may be neurological irritation.

B vitamins are generally absent in the American diet due to the transformation of food which depletes the natural grain sources.  B6 is essential for the metabolism of proteins and is required by all neurotransmitters in the brain for optimal function.  Researchers have long sought to explain that the lack of vitamin c and B6 is intimately associated with cardiovascular disease.  This new study on the influence of vitamin B6 system B6 documents keep inflammation in check.

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Vitamin D May Delay Deterioration of Smokers' Lungs: Study

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Higher Doses of Vitamin D Prevent Fractures in Older Women

HealthDay – 4 mins 43 secs ago WEDNESDAY, July 4 (HealthDay News) -- In the latest study to look at the effect of vitamin D on fracture risk, Swiss researchers found that taking more than 800 international units (IU) of vitamin D daily could reduce the risk of hip fractures in older women by 30 percent.

"Vitamin D supplementation is effective in fracture reduction, including hip fractures," said study author Dr. Heike Bischoff-Ferrari, from the Center on Aging and Mobility at the University of Zurich and Wald City Hospital, also in Zurich.

"However, dose matters, as we saw this benefit only at the highest intake level of greater than 800 IU per day, and no dose below 792 IU per day reduced fracture risk," she said.

If everyone took more than 800 IU of vitamin D daily, the impact on public health could be enormous because hip fractures are the most severe and frequent fractures among the elderly, according to Bischoff-Ferrari.

Results of the study are published in the July 5 issue of the New England Journal of Medicine.

Vitamin D is important for bone health, according to Dr. Anna Lasak, clinical director of the department of rehabilitation and the women's physical medicine and rehabilitation program at Montefiore Medical Center, in New York City. The body makes vitamin D when exposed to sunlight. Sunscreen blocks this effect.

Vitamin D is also found in fatty fish, eggs and some mushrooms, she said. It's also added to dairy products, some cereals and some breads, according to Lasak. But, she said, it can be difficult, especially for elderly people, to get enough vitamin D from these sources. In addition, elderly people may have digestive issues that can cause their bodies to absorb even less vitamin D.

A number of studies have been done looking at vitamin D and bone health, and the studies have often come up with conflicting findings, with some showing benefits, while others found no benefits. In mid-June, the U.S. Preventive Services Task Force recommended that postmenopausal women should not take low-dose vitamin D supplements (400 IU) because there was no evidence of benefit. The task force, however, said there wasn't yet enough clear evidence on higher doses of vitamin D to make a recommendation one way or the other.

The current study is a pooled analysis of 11 double-blind, randomized controlled trials of vitamin D supplementation with or without calcium compared to a placebo or calcium supplementation alone.

The studies included more than 31,000 people. All of the participants in the studies were over 65, with an average age of 76. Most (91 percent) of the volunteers in the studies were women.

They found that people taking less than 800 IU daily showed no statistically significant drop in fracture risk. However, those taking over 800 IU reduced the risk of hip fracture by 30 percent and the risk of non spine-related fractures by 14 percent, according to the study.

"Our data strongly support a daily vitamin D supplement of 800 IU per day in adults age 65 and older to lower their risk of fracture, including those living at home and those living in nursing homes, including men and women, and the younger and the old," Bischoff-Ferrari said.

Lasak said 800 IU is a safe level of vitamin D intake for just about anyone. But, she said, it's better for older folks to have their vitamin D levels measured first. Some may not need additional vitamin D, but many actually need more than 800 IU a day.

"Most people do have a deficiency," she said. While 800 IU is a safe limit, that may not be enough, she said. No one should exceed levels of 4,000 IU, Lasak added. That's the upper safe limit of this nutrient.

She said it's also important to ensure that you're getting enough calcium. The recommendation is for between 1,000 and 1,200 milligrams (mg) a day, with older people needing more, she said. Lasak recommended getting the bulk of your calcium from foods, rather than a supplement, because some studies have suggested possible harm from higher levels of calcium intake from supplements.

Bischoff-Ferrari said the current analysis also suggested that higher levels of calcium supplementation (more than 1,000 mg) may reduce vitamin D's benefit.

More information

Learn more about vitamin D and bone health from the National Osteoporosis Foundation.

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Vitamin D deficiency common among adolescents evaluated for weight-loss surgery

ScienceDaily (June 25, 2012) — Most adolescents preparing for weight-loss, or bariatric, surgery are deficient in vitamin D, a new study demonstrates.

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The results will be presented Tuesday at The Endocrine Society's 94th Annual Meeting in Houston.

"This is particularly important prior to bariatric surgery where weight loss and decreased calcium and vitamin D absorption in some procedures may place these patients at further risk," said study lead author Marisa Censani, M.D., pediatric-endocrinology fellow at Columbia University Medical Center, in New York City. "These results provide insight into prevalence and risk factors for pre-existing vitamin D deficiency in obese adolescents prior to bariatric surgery."

In the United States, weight-loss surgery is becoming an increasingly common procedure due to the obesity epidemic, which affects people of all ages, including children. One of the most common types is gastric-bypass surgery, which involves surgically removing a portion of the stomach, thereby reducing its size and ability to hold large amounts of food. While highly effective at controlling weight, weight-loss surgery presents certain challenges. One of the greatest post-surgical difficulties is maintaining adequate nutrition, particularly with respect to factors associated with bone development since adolescents have not yet reached their peak bone mass.

Vitamin D is found in foods such as eggs, milk, and fish, as well as the sun. The vitamin plays an essential role in regulating the amount of the minerals calcium and phosphorus circulating in the blood.

While previous studies have found an increased risk of vitamin D deficiency among adults evaluated for weight-loss surgery, whether this deficiency also occurred among morbidly obese adolescents remained unclear. Morbid obesity is defined in adults as having a weight-to-height ratio, or BMI, greater than 40; a healthy BMI is no more than 24.9.

In one of the first studies of its kind, Censani and her co-investigators found that more than half of adolescents undergoing evaluation for weight-loss surgery were vitamin D deficient, and 8 percent had severe deficiencies. Slightly less than one-fifth had adequate vitamin D levels. Patients with the highest BMIs were the most likely to be vitamin deficient.

In other findings, investigators identified several racial differences. African Americans were the most likely to be vitamin D deficient, while Caucasians were the least likely to have a deficiency. Specific percentages of vitamin D deficiency among racial subgroups were:

• 82 percent of African Americans

• 59 percent of Hispanics

• 37 percent of Caucasians

"These results support screening all morbidly obese adolescents for vitamin D deficiency, and treating those who are deficient, particularly prior to bariatric procedures that could place these patients at further risk," Censani said.

Investigators analysed the medical records of 236 adolescents who were being considered for bariatric surgery between March 2006 and June 2011. Of these patients, 219 provided medical records that included data on vitamin D levels. Sixty-five percent were female, their average age was 16 years, and average BMI was about 48. Forty-three percent were Caucasian, 35 percent were Hispanic, and 15 percent were African American.

Censani was supported by the NIH National Institute of Diabetes and Digestive and Kidney Diseases 5T32 DK 06552-07 in Pediatric Endocrinology.

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Hidden vitamin in milk yields remarkable health benefits

ScienceDaily (June 14, 2012) — A novel form of vitamin B3 found in milk in small quantities produces remarkable health benefits in mice when high doses are administered, according to a new study conducted by researchers at Weill Cornell Medical College and the Polytechnic School in Lausanne, Switzerland.

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The findings, recently reported in the June 2012 issue of the journal, Cell Metabolism, reveal that high doses of the vitamin precursor, nicotinamide riboside (NR) -- a cousin of niacin -- prevent obesity in mice that are fed a fatty diet, and also increase muscle performance, improve energy expenditure and prevent diabetes development, all without side effects.

The Swiss researchers, led by Dr. Johan Auwerx, performed the mouse experiments, while the ability to give the animals sufficient doses of NR was made possible by Weill Cornell Medical College researchers, who played key roles in uncovering the biological story of NR.

"This study is very important. It shows that in animals, the use of NR offers the health benefits of a low-calorie diet and exercise -- without doing either one," says Dr. Anthony Sauve, associate professor of Pharmacology at Weill Cornell Medical College.

Dr. Sauve is the pharmacologist and organic chemist who has invented a simple method for efficiently synthesizing NR in large scale. He was first to show that NR increases nicotinamide adenine dinucleotide (NAD) levels in mammalian cells. NAD is a central player in energy metabolism. He has pioneered research into the compound, and he is a leader in investigating how NAD can signal adaptation in cells and in physiology.

"The research also suggests that the effects of NR could be even broader," Dr. Sauve says. "The bottom line is that NR improves the function of mitochondria, the cell's energy factories. Mitochondrial decline is the hallmark of many diseases associated with aging, such as cancer and neurodegeneration, and NR supplementation boosts mitochondrial functioning."

The Swiss researchers call NR a "hidden vitamin" that is believed to also be present in many other foods, although levels are low and difficult to measure. Nevertheless, the effects of NR on metabolism "are nothing short of astonishing."

Got nicotinamide riboside?

The study depended on a series of crucial discoveries by Dr. Sauve and his laboratory colleagues.

NR, related to niacin and other common forms of vitamin B3, was first investigated more than 60 years ago by a Stanford researcher and 1959 Nobel Laureate, Arthur Kornberg. But little more was known about its effects in mammals until Dr. Sauve discovered the effect NR had in stimulating levels of NAD in mammalian cells -- work he published in 2007.

NAD allows sugars, fats, and proteins to be converted into energy. Dr. Sauve's research provided the first evidence that NR enhances NAD levels in the mitochondria in mammalian cells in culture. These findings are published in the current study. These cell-based observations were key to the demonstration that NR could stimulate tissue NAD levels in animals, and that it could stimulate NAD-dependent sirtuins, which adapt physiology to the low calorie diets that are known to extend the lifespan of many organisms.

Dr. Sauve invented a relatively simple method for efficiently synthesizing NR in large scale so that its health benefits can be studied. This methodology, which makes it possible to make NR commercially available, was patented by Cornell's Center for Technology Enterprise and Commercialization and subsequently licensed to ChromaDex Corporation.

The development of a means to synthesize NR in adequate quantities was crucial to the current research, and the Sauve lab provided methods and NR to make the study possible. In addition, the biological observations on the effects of NR on NAD levels in cells and on mitochondria were key to the study. Finally, the Sauve laboratory has developed state of the art analytical methods to determine NAD levels in cells, tissues and organelles, and the laboratory provided several key metabolic measurements highlighted in the study.

"Our published scientific work has verified that NR is perhaps the most potent NAD enhancing agent ever identified," he says. His laboratory is also widely recognized for developing an expertise in the measurement of NAD metabolism in cell tissues.

With this compound, the Swiss researchers found that mice on a high-fat diet supplemented with NR gained significantly less weight (60 percent) than mice fed the same diet without NR, even though the mice supplemented with NR ate the same amount of food as mice on the high fat diet not treated with NR. They had improved energy. They were in better shape than the untreated mice, with significantly better endurance and stronger muscles. Additionally, none of the treated mice developed diabetes, as seen in the untreated mice on the high fat diet. And when fed a normal diet, NR treated mice had improved sensitivity to insulin. The NR treated mice also showed lower cholesterol levels. All of these benefits came without toxicity.

While the new study demonstrates that high doses of NR can largely prevent the negative health consequences of a poor diet in mice, Dr. Sauve stresses that the effects of high doses of the vitamin in humans have not been evaluated. "It is important to keep in mind that the amount of NR in milk and other foods appears to be small. We don't know what effects NR would have in humans at relatively high doses," he says.

"Still, we have very encouraging evidence of benefits of NR and NAD augmentation in general from this animal study -- and much more work to do," he says.

The study's senior investigator Dr. Auwerx is head of Laboratory of Integrative Systems Physiology at the Polytechnic School in Lausanne (École Polytechnique Fédérale de Lausanne or EPFL) and the first author is Dr. Carles Cantó, also of EPFL.

Other co-authors include Dou Y. Youn and Dr. Yana Cen from Weill Cornell Medical College; Dr. Riekelt H. Houtkooper, Dr. Eija Pirinen, Dr. Maaike H. Oosterveer, Dr. Pablo J. Fernandez-Marcos, Dr. Hiroyasu Yamamoto, Dr. Pénélope A. Andreux, Dr. Philippe Cettour-Rose, Dr. Kristina Schoonjans and Dr. Chris Rinsch from EPFL; Dr. Karl Gademann from the University of Basel in Switzerland.

The Ellison Medical Foundation New Scholar Award and the New York State Spinal Cord Injury Board funded study contributions by the Weill Cornell Medical College researchers.

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Low Vitamin D Associated with Falls and Loss of Mobility in Elderly

One-third of elderly Americans are blatantly deficient in vitamin D and a majority lack optimal vitamin D for good health.  One quality of health aspect during aging is maintaining the physical ability to get around and do things.  Several new studies point out that vitamin D is needed to maintain physical functionality during aging.

The first study involved 2,099 men and women aged 70-79 who did not have mobility problems at the beginning of the study.  They were tested for vitamin D status and followed for the next six years.  Those with low vitamin D were more likely to develop mobility limitations, including a twofold higher risk for mobility disability.

“This is one of the first studies to look at the association of vitamin D and the onset of new mobility limitations or disability in older adults,” said lead author Denise Houston, Ph.D., R.D., a nutrition epidemiologist in the Wake Forest Baptist Department of Geriatrics and Gerontology.  “It’s difficult to get enough vitamin D through diet alone and older adults, who may not spend much time outdoors, may need to take a vitamin D supplement.  Higher amounts of vitamin D may be needed for the preservation of muscle strength and physical function as well as other health conditions.”

In a separate report published in the Annals of Internal Medicine, the U.S. Preventive Services Task Force has recommended exercise and vitamin D to prevent falls in adults ages 65 and older.  This report is significant because government panels of experts seldom recommend a vitamin for anything, even when the evidence is overwhelming.  In other words, the evidence in support of older people taking vitamin D to prevent falls is overwhelming.  And according to the first study they also need vitamin D to keep active, which is another recommendation of this panel.

I previously reported that researchers have found that increasing vitamin D in the elderly would significantly extend lifespan.  I have also reported that the dose of vitamin D needed to optimize levels is between 4,000 I.U. and 8,000 I.U. per day.  A person does not want to be at the bottom of the normal range on a vitamin D test.  You should strive to be in the middle of the normal range for optimal benefits of vitamin D during aging. 

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Health benefits of vitamin D dependent on type taken

ScienceDaily (May 31, 2012) — New research funded by the Biotechnology and Biological Sciences Research Council (BBSRC) has shown that vitamin D3 supplements could provide more benefit than the close relative vitamin D2. The findings published in the June edition of the American Journal of Clinical Nutrition could potentially lead to changes in the food industry when it comes to fortification.

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Vitamin D is important for bone and muscle health and there is concern that we don't get enough of the 'sunshine' vitamin through exposure to sunlight or through diet. As a result, some foods are fortified with vitamin D. Fortification is usually with vitamin D2, as this is not derived from animals. However this new research, carried out by scientists from the University of Surrey, suggests that vitamin D3 is the more beneficial of the two types of vitamin D in raising the vitamin D levels in our blood when given as a supplement.

The research clearly showed that vitamin D3, the type of vitamin D found in foods including eggs and oily fish, is more effectively converted by the body into the hormone responsible for health benefits in humans.

Dr Laura Tripkovic, who led the study, explains: "We know that vitamin D is vital in helping to keep us fit and healthy, but what has not been clear is the difference between the two types of vitamin D. It used to be thought that both were equally beneficial, however our analysis highlights that our bodies may react differently to both types and that vitamin D3 could actually be better for us."

The researchers analysed the results of 10 separate studies, involving over 1,000 people in total, comparing the health benefits of vitamin D2 and D3, and found "a clear favouring" of vitamin D3 supplements raising vitamin D serum levels in humans.

The researchers are now conducting a further study to see if the same results are found when using lower doses of vitamin D2 and vitamin D3 added to foods, rather than given as stand-alone supplements. Dr Tripkovic and her team will look at over 300 people to find out if vitamin D3 is better, and if so why this is the case. They will also look at how gender, ethnicity and genetic make-up may play a role in how our bodies use both types of vitamin D.

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Older adults may need more vitamin D to prevent mobility difficulties, study suggests

ScienceDaily (May 29, 2012) — Older adults who don't get enough vitamin D -- either from diet, supplements or sun exposure -- may be at increased risk of developing mobility limitations and disability, according to new research from Wake Forest Baptist Medical Center.

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"This is one of the first studies to look at the association of vitamin D and the onset of new mobility limitations or disability in older adults," said lead author Denise Houston, Ph.D., R.D., a nutrition epidemiologist in the Wake Forest Baptist Department of Geriatrics and Gerontology. Houston researches vitamin D and its effects on physical function.

The study, published online this month in the Journal of Gerontology: Medical Sciences, analyzed the association between vitamin D and onset of mobility limitation and disability over six years of follow-up using data from the National Institute on Aging's Health, Aging, and Body Composition (Health ABC) study. Mobility limitation and disability are defined as any difficulty or inability to walk several blocks or climb a flight of stairs, respectively.

Of the 3,075 community-dwelling black and white men and women aged 70-79 who were enrolled, data from 2,099 participants was used for this study. Eligible participants reported no difficulty walking one-fourth mile, climbing 10 steps, or performing basic, daily living activities, and were free of life-threatening illness. Vitamin D levels were measured in the blood at the beginning of the study. Occurrence of mobility limitation and disability during follow-up was assessed during annual clinic visits alternating with telephone interviews every six months over six years.

"We observed about a 30 percent increased risk of mobility limitations for those older adults who had low levels of vitamin D, and almost a two-fold higher risk of mobility disability," Houston said.

Houston said vitamin D plays an important role in muscle function, so it is plausible that low levels of the vitamin could result in the onset of decreased lower muscle strength and physical performance. Vitamin D may also indirectly affect physical function as low vitamin D levels have also been associated with diabetes, high blood pressure, cardiovascular disease and lung disease -- conditions that are frequent causes of decline in physical function. Houston said people get vitamin D when it is naturally produced in the skin by sun exposure, by eating foods with vitamin D, such as fortified milk, juice and cereals, and by taking vitamin D supplements.

"About one-third of older adults have low vitamin D levels," she said. "It's difficult to get enough vitamin D through diet alone and older adults, who may not spend much time outdoors, may need to take a vitamin D supplement."

Current recommendations call for people over age 70 to get 800 International Units of vitamin D daily in their diet or supplements. Houston pointed out that current dietary recommendations are based solely on vitamin D's effects on bone health.

"Higher amounts of vitamin D may be needed for the preservation of muscle strength and physical function as well as other health conditions," she said. "However, clinical trials are needed to determine whether increasing vitamin D levels through diet or supplements has an effect on physical function."

This research was supported in part by the Intramural Research Program of the National Institutes of Health, National Institute on Aging; National Institute on Aging contracts N01-AG-6-2101, N01-AG-6-2103, and No1-AG-6-2106; National Institute on Aging grants R01 AG028050, R01 AG029364 and K01 AG030506 (to DKH); National Institute of Nursing Research grant R01 NR012459; and the Wake Forest University Claude D. Pepper Older Americans Independence Center (P30 AG021332).

Co-authors include: Janet A. Tooze, Ph.D., Gary G. Schwartz, Ph.D., Jeff D. Williamson, M.D., Stephen B Kritchevsky, Ph.D., Rebecca H. Neiberg, Ph.D. and M. Kyla Shea, Ph.D., all of Wake Forest Baptist; Dorothy B. Hausman, Ph.D., and Mary Ann Johnson, Ph.D., University of Georgia, Athens; Jane A. Cauley, Ph.D., University of Pittsburg, Pennsylvania; Doug C. Bauer, M.D., University of California, San Francisco; and Tamara B. Harris, M.D., National Institute on Aging.

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2 oz Niacinamide Face Serum with Vitamin B3 for Younger, Plumper, Firmer Skin

Ingredients,Aloe barbadensis (Organic Aloe Vera) Juice, Kosher Vegetable Glycerin, Niacinamide Vitamin B3, Simmondsia chinensis Oil, Cetearyl Olivate, Sorbitan Olivate, Cetyl Palmitate, Sorbitan Palmitate, Tocopherol Vitamin E, Phenoxyethanol, Caprylyl Glycol, Sorbic Acid, Sodium Hyaluronate , Xanthan Gum , Citric

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Vitamin E in diet protects against many cancers, study suggests

ScienceDaily (Apr. 23, 2012) — Next time you need to choose between vegetable oil and margarine in that favorite recipe, think about your health and reach for the oil.

See Also:Health & MedicineCancerProstate CancerBreast CancerColon CancerVitaminLeukemiaLiving WellReferenceVitamin EB vitaminsVitamin DHealth benefits of tea

While the question of whether vitamin E prevents or promotes cancer has been widely debated in scientific journals and in the news media, scientists at the Center for Cancer Prevention Research, at Rutgers Ernest Mario School of Pharmacy, and the Cancer Institute of New Jersey, believe that two forms of vitamin E -- gamma and delta-tocopherols -- found in soybean, canola and corn oils as well as nuts do prevent colon, lung, breast and prostate cancers.

"There are studies suggesting that vitamin E actually increases the risk of cancer and decreases bone density," says Chung S. Yang, director of the center. "Our message is that the vitamin E form of gamma-tocopherols, the most abundant form of vitamin E in the American diet, and delta-tocopherols, also found in vegetable oils, are beneficial in preventing cancers while the form of vitamin E, alpha- tocopherol, the most commonly used in vitamin E supplements, has no such benefit."

Yang and colleagues, Nanjoo Suh and Ah-Ng Tony Kong, summarized their findings recently in Cancer Prevention Research, a journal of the American Association for Cancer Research. In a Commentary, "Does Vitamin E Prevent or Promote Cancer?"

the Rutgers scientists discuss animal studies done at Rutgers as well as human epidemiological studies that have examined the connection between vitamin E and cancer.

Yang says Rutgers scientists conducting animal studies for colon, lung, breast and prostate cancer found that the forms of vitamin E in vegetable oils, gamma and delta-tocopherols, prevent cancer formation and growth in animal models.

"When animals are exposed to cancer-causing substances, the group that was fed these tocopherols in their diet had fewer and smaller tumors," Yang says. "When cancer cells were injected into mice these tocopherols also slowed down the development of tumors."

In researching colon cancer, Yang pointed to another recently published paper in Cancer Prevention Research indicating that the delta-tocopherol form of vitamin E was more effective than other forms of vitamin E in suppressing the development of colon cancer in rats.

This is good news for cancer research. Recently, in one of the largest prostate cancer clinical trials in the United States and Canada, scientists found that the most commonly used form of vitamin E supplements, alpha-tocopherol, not only did not prevent prostate cancer, but its use significantly increased the risk of this disease among healthy men.

This is why, Yang says, it is important to distinguish between the different forms of vitamin E and conduct more research on its cancer preventive and other biological effects.

"For people who think that they need to take vitamin E supplements," Yang says, "taking a mixture of vitamin E that resembles what is in our diet would be the most prudent supplement to take."

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Vitamin C Supplementation Lowers Blood Pressure

Researchers from the Johns Hopkins School of Medicine evaluated all the vitamin C studies relating to blood pressure dating back to 1966.  They concluded that an average dose of 500 mg of supplemental vitamin C per day for 8 weeks significantly lowered systolic and diastolic blood pressure. 

Vitamin C is one of the grand-daddy antioxidant nutrients and as such is one of the vitamins that the Big Pharma-sponsored American Heart Association loves to hate.  It is actually ironic for mainstream researchers to tout the benefits of vitamin C for cardiovascular health.

Vitamin C is an important antioxidant in your blood that helps to lower inflammation such as CRP C-reactive protein. It is an acute phase protein that increases during systemic inflammation. It is a general way to assess cardiovascular disease risk. A more sensitive test for heart disease risk is hs-CRP, highly sensitive CRP. (C reactive protein).  Vitamin C is needed for collagen synthesis that contributes to flexible arteries.  And vitamin C participates as a member of the antioxidant team that protects your cardiovascular system.

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Vitamin D Doesn't Help Kids Do Better in School, Study Finds

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