EU approves Afinitor for certain breast cancers

Swiss drug maker Novartis AG says it has received European approval to market Afinitor for treatment of women with the most common form of advanced breast cancer.

Afinitor is already approved to treat various tumors of the pancreas, kidney and brain.

The U.S. Food and Drug Administration approved the pill-based drug earlier this month for use in combination with Aromasin for postmenopausal women with recurring hormone receptor positive breast cancer lacking the protein HER2.

Novartis said Monday that the European Commission's approval was based on a trial of more than 700 patients showing those treated with the two drugs lived significantly longer before their disease progressed.

The company said recently its annual sales of Afinitor could rise above the $1 billion mark with the new approvals.

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Experimental Drug Helps Fight Some Childhood Cancers, Study Finds

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Vitamin E in diet protects against many cancers, study suggests

ScienceDaily (Apr. 23, 2012) — Next time you need to choose between vegetable oil and margarine in that favorite recipe, think about your health and reach for the oil.

See Also:Health & MedicineCancerProstate CancerBreast CancerColon CancerVitaminLeukemiaLiving WellReferenceVitamin EB vitaminsVitamin DHealth benefits of tea

While the question of whether vitamin E prevents or promotes cancer has been widely debated in scientific journals and in the news media, scientists at the Center for Cancer Prevention Research, at Rutgers Ernest Mario School of Pharmacy, and the Cancer Institute of New Jersey, believe that two forms of vitamin E -- gamma and delta-tocopherols -- found in soybean, canola and corn oils as well as nuts do prevent colon, lung, breast and prostate cancers.

"There are studies suggesting that vitamin E actually increases the risk of cancer and decreases bone density," says Chung S. Yang, director of the center. "Our message is that the vitamin E form of gamma-tocopherols, the most abundant form of vitamin E in the American diet, and delta-tocopherols, also found in vegetable oils, are beneficial in preventing cancers while the form of vitamin E, alpha- tocopherol, the most commonly used in vitamin E supplements, has no such benefit."

Yang and colleagues, Nanjoo Suh and Ah-Ng Tony Kong, summarized their findings recently in Cancer Prevention Research, a journal of the American Association for Cancer Research. In a Commentary, "Does Vitamin E Prevent or Promote Cancer?"

the Rutgers scientists discuss animal studies done at Rutgers as well as human epidemiological studies that have examined the connection between vitamin E and cancer.

Yang says Rutgers scientists conducting animal studies for colon, lung, breast and prostate cancer found that the forms of vitamin E in vegetable oils, gamma and delta-tocopherols, prevent cancer formation and growth in animal models.

"When animals are exposed to cancer-causing substances, the group that was fed these tocopherols in their diet had fewer and smaller tumors," Yang says. "When cancer cells were injected into mice these tocopherols also slowed down the development of tumors."

In researching colon cancer, Yang pointed to another recently published paper in Cancer Prevention Research indicating that the delta-tocopherol form of vitamin E was more effective than other forms of vitamin E in suppressing the development of colon cancer in rats.

This is good news for cancer research. Recently, in one of the largest prostate cancer clinical trials in the United States and Canada, scientists found that the most commonly used form of vitamin E supplements, alpha-tocopherol, not only did not prevent prostate cancer, but its use significantly increased the risk of this disease among healthy men.

This is why, Yang says, it is important to distinguish between the different forms of vitamin E and conduct more research on its cancer preventive and other biological effects.

"For people who think that they need to take vitamin E supplements," Yang says, "taking a mixture of vitamin E that resembles what is in our diet would be the most prudent supplement to take."

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Genital warts tied to range of cancers

Reuters – 9 hrs ago NEW YORK (Reuters Health) - People who've ever had genital warts may have a somewhat higher risk of several types of cancer -- possibly including common skin cancers, a new study suggests.

The findings, reported in the Journal of Infectious Diseases, confirm some well-established connections between the genital warts virus and certain cancers. And they hint that there could be additional risks.

Genital warts are caused by certain strains of the human papillomavirus (HPV). It's well known that some of those HPV strains -- some of which are the focus of vaccines -- can also promote tumors.

In most people, the immune system is able to clear HPV infection fairly quickly. But some people harbor persistent infections, and a chronic infection with a cancer-linked strain can eventually lead to cancer in some cases.

HPV is probably best known as a cause of cervical cancer -- a disease that experts say is nearly always caused by HPV. The virus is also blamed for most cases of anal cancer, and a large share of vaginal, vulvar and penile cancers.

Lesser known is the link between HPV and certain cancers of the mouth and throat. But a number of studies have found that a large portion of those cancers can be traced to HPV infection.

These latest findings, from a study of more than 49,000 Danish adults, confirm all those connections, said Dr. Susanne Kruger Kjaer of the Danish Cancer Society, who worked on the study.

They also hint that HPV might be involved in the risk of non-melanoma skin cancers -- the most common, and highly curable, types of skin cancer.

CANCER IN LESS THAN FIVE PERCENT

For the study, Kjaer and her colleagues looked at medical records for nearly 33,000 women and 16,000-plus men diagnosed with genital warts over 30 years.

As expected, they had higher-than-average rates of cervical, anal, penile and vaginal cancers, as well as certain mouth and throat cancers.

The vast majority remained cancer-free during the study period. In all, 2,363 people -- or less than 5 percent of the study group -- developed some form of cancer. And only 305 were diagnosed with any of the cancers known to be linked to HPV.

Still, some of those risks were higher than average.

Men with a history of genital warts had a 21 times higher-than-average risk of anal cancer, for instance. Among women, the risk was eight times higher than the norm.

The rates of cervical, penile, vaginal, and mouth and throat cancers were anywhere from 50 percent to eight-times higher, compared with the general population.

There was also some evidence tying genital warts to non-melanoma skin cancers, the researchers say.

Overall, 440 study participants, or less than 1 percent, developed non-melanoma skin cancer -- which is somewhat higher than expected, the researchers say.

It's possible there is some type of connection between HPV and non-melanoma skin cancer, Kjaer told Reuters Health in an email. Since the immune system fights both infections and cancer, it's possible that impaired immune function could underlie persistent HPV infection and skin cancer in some people.

But that's all "speculative" for now, Kjaer stressed.

Non-melanoma skin cancers are the most common type of cancer by far. In the U.S., about 3.5 million cases are diagnosed each year, according to the American Cancer Society.

Experts say the best way to cut your risk of skin cancer is to limit your sun exposure, especially if you have fair skin. No one knows whether preventing HPV infection has any effect.

COULD VACCINES PLAY A ROLE?

For now, there are no "concrete practical implications" from the current findings, Kjaer said.

But if further studies confirm that HPV is associated with a broader range of cancers, that could underscore the importance of preventing the infection, according to Kjaer.

There are two vaccines that can prevent infection with certain cancer-related strains of HPV: Merck's Gardasil and GlaxoSmithKline's Cervarix, both of which cost about $400 for three doses. The current study was funded by Sanofi Pasteur, which sells Gardasil in Europe.

Right now, public health authorities recommend that all girls and boys ages 11 and 12 receive the HPV vaccine. Older girls and young women up to age 26 are advised to get "catch-up" shots if they've never been vaccinated. The same advice goes for boys and men ages 13 to 21.

The HPV vaccine is generally considered safe. The most common side effects are pain at the injection site, fever, dizziness and nausea, according to the U.S. Centers for Disease Control and Prevention.

SOURCE: http://bit.ly/HmRmm2 Journal of Infectious Diseases, online March 15, 2012.

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Half of all cancers are preventable: study

"Half of all cancers could be prevented if people just adopted healthier behaviors, US scientists argued on Wednesday. "Pollution and crime, poor public transportation, lack of parks for play and exercise, and absence of nearby supermarkets for fresh food hinder the adoption and sustained practice of a lifestyle that minimizes the risk of cancer and other diseases," said the study. (AFP Photo/Odd Andersen)" title

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