B12 Levels Predict a Healthier Brain

A study that analyzed the vitamin B121 levels in elderly individuals, age 61-87, found that higher B12 levels were associated with more normal brain size. On the other hand, those with the lowest levels of B12 had the most brain atrophy and were six times more likely to have a problem. 

The study does not talk about B12 deficiency from the point of view of government standards or daily values; people with the lowest B12 levels in this study were not actually deficient according to these standards. However, if one’s brain is shrinking due to a “low-normal” level of a vitamin, then most people would consider that a rather flagrant deficiency of a nutrient.

While supplements were not directly tested in this study to see whether or not they could prevent or reverse the problem, the data suggests that taking B12 is a really good idea for brain health. 

Vitamin B12 is vital to nerve function, as determined by hundreds of studies. Of course, I recommend supplementation with the co-enzyme forms of B12 such as methylcobalamin. Never use the cyanide-producing form known as cyanocobalamin, which is found in many dietary supplements.

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Supplements that contain coenzyme B12
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Hepatitis C Virus Levels Higher in Certain Injection Drug Users

HealthDay – Fri, Jul 13, 2012 FRIDAY, July 13 (HealthDay News) -- Among injection-drug users in the United States infected with hepatitis C, virus levels are highest among blacks, males and those who are also infected with HIV, the virus that causes AIDS, a new study finds.

A 2010 report from the U.S. Centers for Disease Control and Prevention estimates that up to 3.9 million Americans have chronic hepatitis C infection, which is a leading cause of liver cancer, end-stage liver disease and liver transplantation.

The study was published in the July issue of the journal Hepatology.

Previous research indicates that one-third of injection-drug users aged 18 to 30 -- and up to 90 percent of older users -- are infected with the hepatitis C virus. With such high rates, it's important to learn more about the characteristics of infection in this group of people, Dr. Thomas O'Brien, of the Division of Cancer Epidemiology and Genetics at the U.S. National Cancer Institute, said in a journal news release.

O'Brien also noted that hepatitis C virus levels predict treatment response in people with chronic hepatitis C.

O'Brien and colleagues looked at approximately 1,700 black, Hispanic and white injection-drug users in San Francisco. Nearly 75 percent of the participants were men. Their average age was 46 and the average age at which they first used injection drugs was 18.

"We know that the level of

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Lower iron levels seen in newborns of obese mothers

ScienceDaily (July 9, 2012) — A growing number of studies imply that children born to obese mothers face health problems stemming from the womb. New research from the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University and The Mother Infant Research Institute at Tufts Medical Center suggests that low iron status is among these health problems, according to an analysis of maternal hepcidin, a hormone that is key in keeping iron levels balanced.

See Also:Health & MedicineObesityPregnancy and ChildbirthDiet and Weight LossFolic AcidDiseases and ConditionsAnemiaReferenceNutrition and pregnancyBody mass indexMaternal bondFood groups

The study enrolled 15 obese pregnant women with body mass index (BMI) greater than 30 and 15 healthy weight pregnant women with BMIs between 20 and 25 as a control group. Maternal blood draws took place during the second trimester of pregnancy and newborn iron status was measured in cord blood.

The researchers found that being born to an obese mother with elevated hepcidin levels was associated with lower iron status at birth. Obese adults are known to produce higher levels of hepcidin compared to healthy weight adults and the researchers suggest that overproduction of the hormone interferes with the transfer of iron from mother to infant. The results were recently published online by the Journal of Perinatology.

During pregnancy, hepcidin levels are kept at low levels to optimize iron transfer from mother to fetus. "When there is excess hepcidin in a cell, it binds to and inhibits the function of ferroportin, the protein that allows iron to pass through the cell membrane and into the bloodstream," explained senior author Simin Nikbin Meydani, DVM, PhD, director of the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (USDA HNRCA).

"The chronic low-grade inflammation that can result from being obese triggers an abnormal immune response, increasing production of proteins that increase hepcidin levels," added Maria Carlota Dao, first author and a doctoral student in the Nutritional Immunology Laboratory at the USDA HNRCA.

Because iron plays a crucial role in the formation of the central nervous system, children born with iron deficiency are at a greater risk for delays in motor and cognitive development.

"The data on the impact of low maternal iron levels on the fetus comes from undernourished populations," said first author Sarbattama Sen, MD, a neonatologist at Tufts Medical Center and an assistant professor of pediatrics at Tufts University School of Medicine (TUSM). "To the best of our knowledge, ours is the first study to demonstrate that obesity might hamper iron transfer from mother to child and offers some insight into the mechanism of how it occurs. Future studies, however, are needed to confirm the role of obesity associated with inflammation during pregnancy on hepcidin and iron status of the newborn."

The authors further stress that more research is needed before any changes to dietary guidelines or recommendations to obese pregnant women should be considered. Most prenatal vitamin supplements contain 27 milligrams of iron, the daily amount currently recommended by The American Congress of Obstetricians and Gynecologists.

"During pregnancy, women should try to eat a varied, healthy diet while taking the standard prenatal vitamins recommended by their doctors," Sen adds. "Weight gain goals should be based on a woman's BMI prior to becoming pregnant. In 2009, the Institute of Medicine issued new guidelines on weight gain during pregnancy."

Simin Nikbin Meydani is also a professor at the Friedman School of Nutrition Science and Policy at Tufts University and is a member of the immunology program faculty at the Sackler School of Graduate Biomedical Sciences at Tufts University. Additional authors of this study are Chitra Iyer, MD, a former maternal fetal medicine fellow at Tufts Medical Center and David Klebenov, a TUSM student. .

The authors received funding for this study from the USDA, a Tufts Medical Center Research Grant, the Natalie V. Zucker Foundation for Women Scholars, the Stanley N. Gershoff Scholarship and the National Heart Lung and Blood Institute (NHLBI) T32 training program.

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Weight Loss May Increase Testosterone Levels

HealthDay – 31 mins ago WEDNESDAY, June 27 (HealthDay News) -- Shedding pounds may help overweight men with low testosterone boost their levels of the male hormone, new research finds.

Overweight men are more likely to have low levels of testosterone, according to the study, which involved nearly 900 overweight, middle-aged Irish men with pre-diabetes. People with pre-diabetes have abnormally high blood glucose levels, but the levels aren't yet high enough to be considered diabetes.

Men were assigned to one of three treatments. One group was told to eat a lower-fat, lower-calorie diet and exercise at least 150 minutes a week; a second group took the diabetes drug metformin; and a third group took a placebo pill.

Among men in the healthy-lifestyle group, the rate of low testosterone levels dropped from 20 percent to 11 percent after a year. The rate of low testosterone didn't budge in the diabetes-drug group or the placebo group.

The study was expected to be presented this week at the Endocrine Society's annual meeting in Houston.

"Doctors should first encourage overweight men with low testosterone levels to try to lose weight through diet and exercise before resorting to testosterone therapy to raise their hormone levels," study co-author Dr. Frances Hayes, a professor at St. Vincent's University Hospital in Dublin, said in a society news release.

The healthy lifestyle group lost an average of 17 pounds.

"Losing weight not only reduces the risk of pre-diabetic men progressing to diabetes, but also appears to increase their body's production of testosterone," Hayes said.

Because this study was presented at a medical meeting, the data and conclusions should be viewed as preliminary until published in a peer-reviewed journal. Experts also note that the study found an association between weight loss and higher testosterone, but did not prove that losing weight caused testosterone levels to rise.

More information

The American Diabetes Association provides more information on prediabetes.

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Liver fat gets a wake-up call that maintains blood sugar levels

ScienceDaily (May 6, 2012) — A Penn research team, led by Mitchell Lazar, MD, PhD, director of the Institute for Diabetes, Obesity, and Metabolism at the Perelman School of Medicine, University of Pennsylvania, reports in Nature Medicine that mice in which an enzyme called histone deacetylase 3 (HDAC3) was deleted had massively fatty livers, but lower blood sugar, and were thus protected from glucose intolerance and insulin resistance, the hallmark of diabetes.

See Also:Health & MedicineDiabetesObesityDiet and Weight LossLiver DiseaseCholesterolFitnessReferenceBlood sugarDiabetes mellitus type 2Ketone bodiesHyperglycemia

Insulin resistance occurs when the body does a poor job of lowering blood sugars. Typically, patients with obesity and type 2 diabetes have fatty livers, and the dogma in the field, says Lazar, is that the fatty livers contribute to the insulin resistance and diabetes in a vicious cycle. These findings are "a clear counterexample to this thinking," he says.

The researchers observed that the extra fat in the liver did not cause insulin resistance because it was sequestered in tiny lipid droplets inside individual liver cells, coated by a specific protein. The metabolites that would otherwise be used by the body to make glucose were re-routed to make fat, leading to reduced glucose in the bloodstream. The advantage of the lower blood sugar is tempered by the excess liver fat, which can lead to problems of its own, including liver failure.

Cells of high-fat-diet-induced fatty livers in wild-type mice were characterized by larger lipid droplets, but liver-specific HDAC3 knockout mice on a high-fat diet were characterized by smaller lipid droplets, even though the total lipid content increased versus the wild-type mice.

Why would the body have this re-routing process in the first place? The team looked to the circadian rhythm of the nocturnal mice for answers. When inactive during the day, mouse HDAC3 migrates to genes to turn off fat synthesis. This allows metabolites to make glucose for fueling the sleeping body. When waking, during the night, the mouse body makes a metabolic switch, anticipating the intake of food, and turns on fat synthesis for energy storage. The on-and-off cycle of HDAC3 is directly regulated by the internal circadian clock, and the system falls apart when HDAC3 is deleted.

The findings suggest that the cordoning off of lipids of the liver in many, tiny coated droplets helps to manage insulin resistance in the body. And, the findings cement the fact that HDAC3 is pivotal in integrating signals from the internal body clock to coordinate metabolism, especially in the liver, notes the first author Zheng Sun, PhD, postdoctoral fellow in the Lazar lab.

The findings demonstrate that fat itself is not necessarily all bad. "It matters a lot how fat is handled and stored," notes Lazar. "It also highlights the importance of complying with our internal circadian clock. For example, since our body does not anticipate food at night and is preparing to generate more glucose, night-time eating is likely to shoot up blood sugar and thus may contribute to diabetes."

The work was funded in part by National Institute of Diabetes and Digestive and Kidney Diseases (R37 DK43806; P01 DK49210; R01 DK40936; R01 DK075017); the Cox Institute of Medical Research; and the JPB Foundation.

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CDC: Americans' Levels of Vitamins, Nutrients Basically OK

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Popcorn: The snack with even higher antioxidants levels than fruits and vegetables

ScienceDaily (Mar. 25, 2012) — Popcorn's reputation as a snack food that's actually good for health popped up a few notches as scientists recently reported that it contains more of the healthful antioxidant substances called "polyphenols" than fruits and vegetables.

See Also:Health & MedicineVegetarianNutritionVitamin CPlants & AnimalsFoodAgriculture and FoodBotanyLiving WellReferenceWhole grainFood groupsBrown riceBran

They spoke at the 243rd National Meeting & Exposition of the American Chemical Society (ACS), in San Diego on March 25.

Joe Vinson, Ph.D., a pioneer in analyzing healthful components in chocolate, nuts and other common foods, explained that the polyphenols are more concentrated in popcorn, which averages only about 4 percent water, while polyphenols are diluted in the 90 percent water that makes up many fruits and vegetables.

In another surprising finding, the researchers discovered that the hulls of the popcorn -- the part that everyone hates for its tendency to get caught in the teeth -- actually has the highest concentration of polyphenols and fiber.

"Those hulls deserve more respect," said Vinson, who is with the University of Scranton in Pennsylvania. "They are nutritional gold nuggets."

The overall findings led Vinson to declare, "Popcorn may be the perfect snack food. It's the only snack that is 100 percent unprocessed whole grain. All other grains are processed and diluted with other ingredients, and although cereals are called "whole grain," this simply means that over 51 percent of the weight of the product is whole grain. One serving of popcorn will provide more than 70 percent of the daily intake of whole grain. The average person only gets about half a serving of whole grains a day, and popcorn could fill that gap in a very pleasant way."

Vinson cautioned, however, that the way people prepare and serve popcorn can quickly put a dent in its healthful image. Cook it in a potful of oil, slather on butter or the fake butter used in many movie theaters, pour on the salt; eat it as "kettle corn" cooked in oil and sugar -- and popcorn can become a nutritional nightmare loaded with fat and calories.

"Air-popped popcorn has the lowest number of calories, of course," Vinson said. "Microwave popcorn has twice as many calories as air-popped, and if you pop your own with oil, this has twice as many calories as air-popped popcorn. About 43 percent of microwave popcorn is fat, compared to 28 percent if you pop the corn in oil yourself."

Likewise, Vinson pointed out that popcorn cannot replace fresh fruits and vegetables in a healthy diet. Fruits and vegetables contain vitamins and other nutrients that are critical for good health, but are missing from popcorn.

Vinson explained that the same concentration principle applies to dried fruit versus regular fruit, giving dried fruit a polyphenol edge. Previous studies found low concentrations of free polyphenols in popcorn, but Vinson's team did the first study to calculate total polyphenols in popcorn. The amounts of these antioxidants were much higher than previously believed, he said. The levels of polyphenols rivaled those in nuts and were up to 15 times greater than whole-grain tortilla chips.

The new study found that the amount of polyphenols found in popcorn was up to 300 mg a serving compared to 114 mg for a serving of sweet corn and 160 mg for all fruits per serving. In addition, one serving of popcorn would provide 13 percent of an average intake of polyphenols a day per person in the U.S. Fruits provide 255 mg per day of polyphenols and vegetables provide 218 mg per day to the average U.S. diet.

Michael G. Coco, an undergraduate chemistry student at the University of Scranton who participated in the study, said he benefited in several ways.

"From working on this project with Dr. Vinson, I've gained experience and many insights in doing scientific research," said Coco. "Besides the obvious things like learning how to use instrumentation and perform analyses, I've also learned that research is extremely satisfying, especially when you discover or think of something no one else has thought of."

The scientists acknowledged funding from the University of Scranton.

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Low 'Bad' Cholesterol Levels May Be Linked to Cancer Risk

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