Friday, June 15, 2012

Bonobo Genome Sheds Light on Their Links to Chimps, Humans

HealthDay – 4 mins 26 secs ago WEDNESDAY, June 13 (HealthDay News) -- Scientists who have completed the genome of the bonobo say their research will provide insights into the species' evolutionary relationships with other great apes and with humans.

The bonobo is the last of the great apes to have its genome sequenced. Other great apes include the chimpanzee, orangutan and gorilla.

Bonobos and chimpanzees are the closest living relatives of humans. But in contrast to the more aggressive chimpanzees, bonobos are known for their peaceful, playful behavior.

The bonobo genome was sequenced from a female named Ulindi who lives at the Leipzig zoo in Germany. The results show that bonobos and chimpanzees differ genetically by about 0.4 percent, while both bonobos and chimpanzees differ from humans by about 1.3 percent.

The study, by Kay Prufer and colleagues at the Max Planck Institute for Evolutionary Anthropology in Leipzig, is published in the June 13 online edition of the journal Nature.

Bonobo and chimpanzee territories in central Africa are separated only by the Congo River. It's been theorized that the formation of the river separated the ancestors of chimpanzees and bonobos, leading to distinct species. This hypothesis is supported by a comparison of the bonobo and chimpanzee genomes, which shows an apparent clean split and no subsequent interbreeding.

While the average genomes of bonobos and chimpanzees are equally distant from the human genome, humans are closer to bonobos in some regions and closer to chimpanzees in others.

Further research will determine whether these genome regions influence the behavioral differences and similarities between humans, chimpanzees and bonobos, the study authors said.

More information

The Great Ape Trust has more about bonobos.



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Targeted Radiation for Lung Cancer May Carry Risks

HealthDay – 4 mins 23 secs ago WEDNESDAY, June 13 (HealthDay News) -- A woman with early-stage lung cancer died recently after highly targeted radiation therapy zapped not just her tumor, but surrounding tissue, fatally damaging her airway.

Though just a single case report of an apparently deadly complication, the authors warn that targeted radiation therapy -- specifically, stereotactic body-radiation therapy -- has inherent risks, even when done properly and using an even lower dose of radiation than is considered safe.

Stereotactic body-radiation therapy focuses beams of radiation on a tumor in the hopes of killing it. Because it uses highly precise beams that can focus large doses of radiation with millimeter accuracy, the technique is considered an advance over older types of radiation therapy, which are generally more diffuse, explained Dr. Len Lichtenfeld, deputy chief medical officer for the American Cancer Society. The goal is to reduce exposure of healthy tissue to the radiation to avoid side effects, while more effectively shrinking the tumor with the higher doses of radiation delivered over a shorter period of time.

Stereotactic radiation is increasingly used to treat early-stage lung cancer. Though the first choice of treatment for early-stage lung cancer is surgery, radiation is turned to in people who cannot withstand having a portion of their lung removed because of other health issues, such as serious underlying heart or lung disease, said Dr. Ramesh Rengan, an assistant professor of radiation oncology at University of Pennsylvania Perelman School of Medicine.

Rengan wrote the case report published in the June 14 issue of the New England Journal of Medicine.

In the case report, a 61-year-old woman with a history of smoking and stage 1 adenocarcinoma -- meaning the two tumors were small and had not spread to the lymph nodes or other organs -- was treated, seemingly successfully, with stereotactic body radiation. Adenocarcinoma is a common type of non-small cell lung cancer.

But eight months later, not only did the woman have new metastases (spread of the cancer), a bronchoscopy -- a camera threaded into the airway -- showed an "extensive area of necrosis," or dead tissue, near the radiated area.

Her physicians at University of Pennsylvania did not do additional radiation. Instead, she underwent more chemotherapy, but began coughing up blood and died a few months later.

Researchers warned that patients with tumors near "radiation-sensitive" body parts, or body parts easily damaged by radiation relative to the dose needed to treat the cancer, such as the large airways, large blood vessels, the heart, certain nerves and the spinal cord, "may be at increased risk for severe radiation injury."

"The reason why it's so important to get this message out is because these side effects don't manifest themselves immediately. They can take months to show up," Rengan said. "And you will only find them if you are looking. Most patients aren't undergoing bronchoscopy just for the heck of it. On a CT scan, the airway looks fine."

Rengan urged physicians who use stereotactic radiation to follow patients carefully. Furthermore, the levels of radiation that are considered safe may need to be rethought, he added.

"This was a dose level that was previously believed to be safe for this type of tumor in this location," he said.

Lichtenfeld praised the authors for writing the case report. Although one report does not have the weight of a clinical trial involving multiple patients from multiple institutions, anecdotal reports such as this can help raise awareness about the potential complications of a treatment that's increasingly popular.

"Even though the doctors gave the radiation properly, they still got a serious complication," Lichtenfeld said. "What this report is saying is even though we did this the right way, doctors and patients still need to be aware you can have bad effects from this type of radiation used in this way."

More information

The U.S. National Cancer Institute has more on lung cancer.



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Birth Control That Uses Combined Hormones Raises Heart Risk: Study

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Fertility Treatment Tied to Higher Relapse Rate in Women With MS

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Plague Rare in U.S., Surfacing in More Affluent Areas

HealthDay – 4 mins 13 secs ago WEDNESDAY, June 13 (HealthDay News) -- Although the plague is typically considered a remnant of the Middle Ages, when unsanitary conditions and rodent infestations prevailed amid the squalor of poverty, this rare but deadly disease appears to be spreading through wealthier communities in New Mexico, researchers report.

Why the plague is popping up in affluent neighborhoods isn't completely clear, the experts added.

"Where human plague cases occur is linked to where people live and how people interact with their environment," noted lead researcher Anna Schotthoefer, from the Marshfield Clinic Research Foundation in Wisconsin. "These factors may change over time, necessitating periodic reassessments of the factors that put people at risk."

This latest study confirms previous reports that living within or close to the natural environments that support plague is a risk factor for human plague, Schotthoefer said.

Plague is caused by a fast-moving bacteria, known as Yersinia pestis, that is spread through flea bites (bubonic plague) or through the air (pneumonic plague).

The new report comes on the heels of the hospitalization on June 8 of an Oregon man in his 50s with what experts suspect is plague. According to The Oregonian, the man got sick a few days after being bitten as he tried to get a mouse away from a stray cat. The cat died days later, the paper said, and the man remains in critical condition.

For the new study, published in the July issue of Emerging Infectious Diseases, the researchers used U.S. Census Bureau data to pinpoint the location and socioeconomic status of plague patients.

About 11 cases of plague a year have occurred in the United States since 1976, with most cases found in New Mexico. Plague has also been reported in a handful of other states.

Although many cases were in areas where the habitat supports rodents and fleas, the researchers also found cases occurring in more upper-class neighborhoods. In the 1980s, most cases occurred where housing conditions were poor, but more recently cases have been reported in affluent areas of Santa Fe and Albuquerque, the investigators found.

"The shift from poorer to more affluent regions of New Mexico was a surprise, and suggests that homeowners in these newly developed areas should be educated about the risks of plague," Schotthoefer said.

Schotthoefer noted that these more affluent areas where plague occurred were regions where new housing developments had been built in habitats that support the wild reservoirs of plague, which include ground squirrels and woodrats.

Bubonic plague starts with painful swellings (buboes) of the lymph nodes, which appear in the armpits, legs, neck or groin. Buboes are at first a red color, then they turn a dark purple color, or black. Pneumonic plague starts by infecting the lungs. Other symptoms include a very high fever, delirium, vomiting, muscle pains, bleeding in the lungs and disorientation.

In the 14th century, a plague called the Black Death killed an estimated 30 percent to 60 percent of the European population. Victims died quickly, within days after being infected.

Infectious disease expert Dr. Marc Siegel, an associate professor of medicine at NYU Langone Medical Center in New York City, said he doesn't expect to see that kind of outbreak ever again.

"This is not a disease of the past, but you are never going to see a massive outbreak of plague in this country," he said.

"We don't have the public health problems we used to have and people would be quickly confined if there were ever a large number of cases," Siegel explained.

Yet, it is not surprising to see plague in these more affluent areas, he noted.

"We know that plague only exists where you have wild animals, and once a reservoir of plague is already present it is likely to persist," Siegel explained. "It isn't only about squalor; it's about where the reservoir is."

However, if the disease is caught early it is treatable with antibiotics, Siegel added.

More information

For more information on plague, visit the U.S. National Library of Medicine.



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Guidelines Issued for When Docs Should Order Vascular Testing

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Violence Takes a Toll on Children's Sleep

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Scientists Probe Diversity of Human Body's Microbes

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Young Kids With Hip, Thigh Fractures Heal Well With Single-Leg Casts

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Mouse Study Suggests Certain Fats Could Trigger Crohn's, Colitis

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Sleep Apnea Treatment Might Boost Men's Sex Lives

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Vein grown from stem cells saves 10-year-old girl

Reuters – 4 hrs ago LONDON (Reuters) - Doctors in Sweden have replaced a vital blocked blood vessel in a 10-year-old girl using the first vein grown in a lab from a patient's own stem cells.

The successful transplant operation, reported online in The Lancet medical journal on Thursday, marks a further advance in the search for ways to make new body parts.

It could open the door to stem cell-based grafts for heart bypass and dialysis patients who lack suitable blood vessels for replacement surgery, and the Swedish team said it is now working with an undisclosed company to commercialize the process.

"I'm very optimistic that in the near future we will be able to get both arteries and veins transplanted on a large scale," said Suchitra Sumitran-Holgersson, professor of transplantation biology at the University of Gothenburg, and a member of the team that performed the operation in March 2011.

The advantage of using tissue grown from a patient's own cells is that there is no risk of organ rejection and hence no need for lifelong immunosuppressive drugs.

Four years ago, a 30-year-old woman received the world's first transplant of a tailor-made windpipe, grown in a similar way by seeding a stripped-down donor organ with her own stem cells. Other such trachea operations have followed since.

The latest case involved a young girl with an obstructed hepatic portal vein, which drains blood from the intestines and spleen to the liver. Its blockage can be fatal.

The team from the University of Gothenburg took a 9 cm (3.5 inch) section of groin vein from a deceased donor and removed all the living cells, leaving just a protein scaffold tube. Stem cells extracted from the girl's bone marrow were then injected onto the tube and two weeks later the graft was implanted.

The new blood vessel immediately restored normal blood flow, the doctors said, although after a year it narrowed and a second stem cell-based graft was needed.

Martin Birchall and George Hamilton of University College London said in a commentary in The Lancet that the Swedish doctors had spared the young girl the trauma of having veins harvested from deep in her neck or leg and avoided the need for a liver transplant.

But they cautioned the technique now needed to be tested in clinical trials and developed into a straightforward quality-controlled production process.

Sumitran-Holgersson said her team had already simplified the process and was now able to harvest stem cells from blood rather than bone marrow. She aims to test the technique with arteries later this year.

"You are going to see more and more of these personalized grafts in future," she said in a telephone interview.

The university has also linked up with a Swedish company, which Sumitran-Holgersson declined to identify, to explore how to commercialize the technique. This could involve offering "off-the-shelf" scaffolds from which tailor-made blood vessels could then be built.

Around the world, scientists in the emerging field of regenerative medicine are working to engineer many different human organs and tissues in the lab, including lungs and hearts.

Building such complex organs is a lot more challenging than making blood vessels, however, since veins are relatively simple hollow structures with few engineering demands.

(Editing by Alessandra Rizzo)



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