Friday, April 27, 2012

Leaded Gas Exposure Linked to Later Violence: Study

HealthDay – 4 hrs ago WEDNESDAY, April 25 (HealthDay News) -- Urban areas contaminated decades ago by airborne lead dust now face an increased incidence of aggravated assault, according to a new study.

The surge in violence is linked to exposure to the lead dust emitted from older vehicles that ran on leaded gasoline, according to the researchers, who say improper handling of lead-based paint could have played a role as well.

"Children are extremely sensitive to lead dust, and lead exposure has latent neuroanatomical effects that severely impact future societal behavior and welfare," said study co-author Howard Mielke, a research professor in the pharmacology department at the Tulane University School of Medicine, in a Tulane news release.

The researchers compared the amount of lead released from 1950 to 1985 in Atlanta, Chicago, Indianapolis, Minneapolis, New Orleans and San Diego.

Exposure to lead dust in the air surged during that time period because of the use of leaded gasoline, the study found. Two decades later, rates of aggravated assault in those cities increased as well. Exposure to lead dust had negative effects on children's behavior as adults, according to the researchers, who said the association held true even after they took other factors into consideration, such as household income and education.

The current rate of aggravated assault rose by almost one-half of a percentage point for every 1 percent increase in tonnages of environmental lead that was released more than two decades earlier, the study found.

"Up to 90 percent of the variation in aggravated assault across the cities is explained by the amount of lead dust released 22 years earlier," Mielke said in the release.

The study is published online, ahead of print publication in the August issue of the journal Environment International.

While the study found an association between lead contamination and future violence, it did not prove a cause-and-effect relationship.

More information

The U.S. Environmental Protection Agency provides more information on lead in dust.



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Thursday, April 26, 2012

Poor Sleep Heightens 'Ringing Ear' Disease Symptoms: Study

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Many Who First Misuse Prescription Pills Get Them From Friends, Family: Report

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Heroin Addicts Have Higher Pain Sensitivity, Even During Treatment

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Donor Kidney Re-Used in Second Patient After Failing in First

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Low-Radiation CT Scans Effective at Spotting Appendicitis: Study

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Warnings on Cigarette Packs May Keep Ex-Smokers From Relapse

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Aromatherapy: More Than Just a Pleasant Scent?

HealthDay – 4 hrs ago WEDNESDAY, April 25 (HealthDay News) -- Aromatherapy is beginning to enter the medical mainstream, with groups as diverse as the American Cancer Society and the U.S. Department of Veterans Affairs touting the use of fragrance as a therapy that can complement traditional health care.

There's little evidence to suggest that aromatherapy can directly cure illness, but research has found it can help reduce a wide range of symptoms and side effects in some people.

"Many specific ailments can benefit from aromatherapy blends and treatments," said Monika Meulman, president of the Canadian Federation of Aromatherapists. "For example, insomnia, nausea, headaches and migraines, and aches and pains are often improved with aromatherapy -- just to name a few."

Aromatherapy involves the use of what are called essential oils, which are very potent distillations of the fragrant portions of plant life such as flowers, roots and bark, said Dr. Hal Blatman, medical director of the Blatman Pain Clinic in Cincinnati and a past president of the American Holistic Medical Association.

These oils are either applied topically to the body, through a cream or a soaking bath, for instance, or are inhaled after they've been diffused into the air in a room, Meulman explained.

Researchers believe that the oils trigger smell receptors in the nose, prompting the transmission of chemical messages along nerve pathways to the brain's limbic system, Blatman said. The limbic system is a part of the brain closely associated with moods and emotion.

"It's easy to see smells have an effect on the body," Blatman said. "Smells have deep emotional triggers in people."

Aromatherapists recommend using different oils for different effects. For example:

Lavender and rosemary oil are suggested for relieving muscle tension and anxiety.Peppermint and ginger oil may relieve nausea and help perk up a fatigued person.Eucalyptus oil is considered helpful in treating respiratory ailments -- something known by the legions of kids who've had Vicks VapoRub smoothed onto their chest.

The oils also can be layered on to get a combination of effects, Blatman said.

"There are all kinds of specific conditions and specific remedies," he said. "There are a number of reference books for how to use the oils."

The potential plusses of aromatherapy, however, come with possible drawbacks, too.

For instance, people who decide to pursue aromatherapy on their own need to be careful because the essential oils used are very strong, Meulman and Blatman said. The oils can cause an allergic reaction when touched or inhaled and can prompt an asthma attack in some people.

The quality of essential oils also can change over time.

"Often the oils sitting on the shelf in a health food store are no longer viable -- they break down with time -- and may no longer have active compounds in them," Meulman said. "Many essential oils are only effective for several months to a year. By the time they get to an end user, they have oxidized to the point of not being useful and, in some cases, may be harmful."

People also should be aware that the oils can have an internal effect even if applied to the skin.

"Some essential oils can accumulate in the liver," Meulman said. "For example, eucalyptus is broken down slowly by the body and tends to accumulate in the liver. If used daily in large amounts, within a few weeks a person can experience signs of toxicity due to this buildup."

For these reasons and others, Meulman and her association recommend that people interested in aromatherapy consult with a professional aromatherapist.

"For do-it-yourself use, one can use some oils for ambiance, room spray experiences and other such occasional uses," she said. "For daily aromatherapy use and self-treatment, professional aromatherapist guidance is strongly advised."

More information

The National Association for Holistic Aromatherapy has more on aromatherapy.



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Senate passes postal bill that would end Saturday mail

Reuters – 3 hrs ago (Reuters) - The Senate advanced legislation on Wednesday that would allow the U.S. Postal Service to end Saturday mail after two years as part of efforts to overhaul the mail agency and prevent it from shuttering thousands of facilities next month.

The Postal Service has been losing billions of dollars each year due to the rise of online communications and high labor and other costs. Both houses of Congress have been working for months on legislation to restructure the agency and offer some relief.

The Senate voted 62-37 to pass its bill, which would also let the mail agency use about $11 billion in surplus funds in a retirement account to offer early retirement incentives as a means to reduce its workforce.

But while the bill was sponsored by a bipartisan coalition of senators, it faces a difficult challenge in the Republican-led House of Representatives. Leaders have yet to schedule a full House vote on the leading bill, which differs significantly from the Senate version, even though a committee approved it in October.

"This bill will bring the change that the post office needs to stay alive and serve the people and businesses of our country," Independent Senator Joe Lieberman, one of the Senate bill's sponsors, said before the vote.

"Now we've got to challenge the House" to pass a bill, he told reporters afterward.

The Postal Service lost more than $3 billion last quarter, much of it due to a massive annual payment for future retiree health benefits. Postmaster General Patrick Donahoe has said the agency needs to cut operating costs by $20 billion by 2015, including ending Saturday mail delivery, taking over its health care plan and raising postage rates beyond inflation.

The agency also intends to close thousands of money-losing post offices and hundreds of mail processing facilities.

Postal officials agreed late last year to a moratorium on closings through mid-May to give Congress time to pass legislation. The Senate bill would place some restrictions on which facilities can be closed, requiring the Postal Service to consider factors such as Internet access before closing a post office.

The final version of the bill also forces the Postal Service to keep some post offices open until after November elections to protect by-mail voting and to maintain rural post offices that are more than 10 miles away from another location.

PRESSURE ON HOUSE

The bill's sponsors said after the vote on Wednesday they hope the approaching end of the closings moratorium puts pressure on the House to act on its bill.

The leading House bill, from Republican Representative Darrell Issa, takes a different approach to reform, creating oversight groups to close post offices and cut costs.

"I talked earlier today to Congressman Issa on the House side to encourage him to move the House version of postal reform, which is very different from our approach," Republican Senator Susan Collins told reporters.

Issa, who heads the House Oversight Committee, has criticized the Senate bill for returning the retirement-fund surplus and for restricting the post offices and processing facilities that can be closed.

"Instead of finding savings to help the Postal Service survive, the Senate postal bill has devolved into a special interest spending binge that would actually make things worse," he said in a statement on Wednesday.

Others, including rural-state lawmakers, took the opposite tack, criticizing the Senate for allowing the mail agency to close facilities.

Senator Joe Manchin, a Democrat, offered an amendment that would have extended for two years the moratorium on closings. His amendment failed to obtain the needed 60 votes on Wednesday, and he voted against the final bill.

"Without the inclusion of a two-year moratorium, I will not support the final passage of the Postal Reform bill," Manchin tweeted.

Postal unions had also criticized the bill, with some organizing rallies and asking Twitter followers to tell their senators to vote against the bill.

Fredric Rolando, president of the National Association of Letter Carriers, called the bill "flawed" in a statement on Wednesday and said the group would continue to fight for a postal overhaul that would eliminate the annual retiree health payment and not allow the agency to end thousands of jobs.

(Reporting by Emily Stephenson; editing by Todd Eastham)



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FDA advisers back HeartWare blood pump device

Reuters – 3 hrs ago WASHINGTON (Reuters) - HeartWare International Inc won a U.S. advisory panel's support on Wednesday for its most important product - a blood pump that helps people with severe heart failure.

A panel of outside experts to the Food and Drug Administration voted 9-2 to recommend approval of the mechanical heart-assist device, called the HeartWare ventricular assist device (HVAD). HeartWare shares were halted pending the panel outcome.

The FDA usually follows panel advice, although it is not required to and a final decision is expected later.

Panelists said the device helped save lives, although they expressed doubts about the company's conduct of clinical trials and about missing safety data.

"Overall, this is a novel device for a desperate population, and I hope it will be available soon," said panel member Dr. David Slotwiner, of the Long Island Jewish Medical Center.

Heart failure is a chronic condition with no cure, in which the heart is too weak to pump enough blood to meet the body's needs. In the most severe cases, people may need a heart transplant.

HeartWare's device helps people with failing hearts pump blood while awaiting a transplant. The device is already approved in Europe.

It is estimated that some 50,000 people around the world are candidates for heart transplant, but only some 5,000 patients per year get them.

But reviewers from the FDA said earlier this week they were concerned about device-related clotting rates and stroke. FDA reviewers and outside experts to the agency also said clinical trial results may have missing data, meaning they could over-estimate how well the device works.

"In terms of safety, these data have more holes in them than Swiss cheese," said panel member Dr. Gregory Dehmer, of Texas A&M University.

Panel members called for HeartWare to conduct further safety trials if the FDA approves its device.

If approved, the device will compete with Thoratec Corp's HeartMate II, which has been sold in the United States since 2008. It is currently the only blood pump available to people with heart failure awaiting a transplant.

Thoratec shares fell 1.5 percent in after-market trading.

Many investors have been betting HeartWare's device will eventually eclipse the HeartMate II since it is smaller and takes less time to implant. However, concerns about pump-associated thrombosis, or the formation of blood clots, as well as stroke issues, could hurt market share.

HeartWare said it changed the instructions for doctors using the device to reduce the risk of clots and there was no evidence strokes in clinical trials were linked to its device.

"Each device is going to have its relative strengths and our patients deserve these options," said Dr. Keith Aaronson, a paid consultant for HeartWare and professor of internal medicine at the University of Michigan. "And as a cardiologist treating patients with advanced heart failure, I feel strongly we need to have competition in this field."

(Editing by Gary Hill, Bernard Orr and Andre Grenon)



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Analysis: U.S. mad cow find: lucky break or triumph of science?

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Feds weigh pulling drug licenses for two Florida CVS stores

Reuters – 3 hrs ago ARLINGTON, Va (Reuters) - A federal hearing began on Wednesday on whether to bar two CVS Caremark Corp drugstores in Florida from selling potentially addictive painkillers as part of a government crackdown on prescription pain pills, especially oxycodone.

The CVS drugstores, both in Sanford, ranked 23rd and 37th respectively among the thousands of U.S. pharmacies for distribution of oxycodone, Drug Enforcement Administration (DEA) district supervisor Gayle Lane told the court.

The DEA has increased its focus on drug wholesalers and pharmacies as it tries to battle what the Centers for Disease Control and Prevention call a prescription drug abuse "epidemic." Deaths from narcotic painkillers now top those of heroin and cocaine combined.

A pharmacist at one store told investigators in October 2011 that sometimes the store would run out of oxycodone as soon as 30 minutes after opening at 8 a.m and most days between 10 a.m. and noon, DEA investigator Heather Wehrle testified.

"He stated he could fill oxycodone prescriptions all day long if he had the manpower and the inventory," Wehrle said.

The DEA has alleged that the two stores, about 30 miles south of Orlando, were inappropriately filling prescriptions for oxycodone, which can be highly addictive, and also had suspicious sales of other controlled substances.

The hearing before Administrative Law Judge John Mulrooney II is expected to run through the end of next week, with a decision to follow later.

CVS has contended that the high volume of oxycodone and other prescription painkillers from the two stores arose because they were busy pharmacies, being close to Interstate Highway 4, and one store was open 24 hours a day.

The hearing follows a move by the DEA to prevent the two CVS pharmacies in Florida from selling controlled substances and to suspend Cardinal Health Inc's license to distribute controlled substances from its plant in Lakeland, Florida. The companies also are fighting the orders in court.

NOTHING TO GAIN

CVS attorney Catherine O'Neil told Mulrooney the two stores had effective controls in place, such as taking hours to verify prescriptions, and had installed new guidelines in October 2011.

The company also has replaced the chief pharmacists at the stores.

She said employees had no incentive to sell painkillers, adding, "They had nothing to gain and everything to lose if they failed to meet their obligations."

DEA group supervisor Ruth Carter said her checks with Cardinal Health, which supplies oxycodone, had shown that Cardinal had shipped 7.5 million pills to the two CVS stores over 36 months.

Carter said records at the two stores showed that they consistently were filling "prescription cocktails" - a mix of oxycodone and anti-anxiety drugs and muscle relaxers -- with the same diagnosis of lower back, or lumbar, pain.

The DEA has suspended Cardinal Health's license to distribute controlled substances - drugs that are liable to abuse - from its plant in Lakeland, Florida.

Florida has long been considered the center of prescription drug abuse. Susan Langston, the acting DEA manager overseeing the diversion of prescription drugs in Florida, testified that 98 of the top 100 doctors prescribing oxycodone in the United States were in Florida, and more of the painkiller was dispensed in the state than the rest of the country combined.

The DEA this month said it was inspecting six Walgreen Co pharmacies and its distribution center in Florida after the agency noticed a jump in purchases of oxycodone.

(Reporting by Ian Simpson; Editing by Lisa Shumaker)



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