Have Younger Skin in Under a Month

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Thicker eyelashes

Have Younger Skin in Under a MonthRecent CommentsMr WordPress on Hello world!ArchivesMarch 2012February 2012January 2012December 2011November 2011October 2011September 2011August 2011July 2011June 2011May 2011April 2011March 2011February 2011Alexa RankCategoriesAnti AgingDentalFitnessHair LossSkin CareUncategorizedWeight LossMetaLog inEntries RSSComments RSSWordPress.org You are here: Home > Hair Loss > Posted in Hair Loss

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Fat Burning Furnace Secrets

Thicker eyelashesHave Younger Skin in Under a MonthDental Care Tips for Healthy and Strong TeethRecent CommentsMr WordPress on Hello world!ArchivesMarch 2012February 2012January 2012December 2011November 2011October 2011September 2011August 2011July 2011June 2011May 2011April 2011March 2011February 2011Alexa RankCategoriesAnti AgingDentalFitnessHair LossSkin CareUncategorizedWeight LossMetaLog inEntries RSSComments RSSWordPress.org You are here: Home > Weight Loss > Posted in Weight Loss

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Compounds dramatically alter biological clock and lead to weight loss, animal study suggests

ScienceDaily (Mar. 29, 2012) — Scientists from the Florida campus of The Scripps Research Institute have synthesized a pair of small molecules that dramatically alter the core biological clock in animal models, highlighting the compounds' potential effectiveness in treating a remarkable range of disorders -- including obesity, diabetes, high cholesterol, and serious sleep disorders.

See Also:Health & MedicineDiet and Weight LossObesityMind & BrainDieting and Weight ControlInsomniaPlants & AnimalsMiceAgriculture and FoodReferenceCircadian rhythmCircadian rhythm sleep disorderJet lagDiabetes mellitus type 2

The study was published on March 29, 2012, in an advance, online edition of the journal Nature.

The study showed that when administered in animal models the synthetic small molecules altered circadian rhythm and the pattern of core clock gene expression in the brain's hypothalamus, the site of the master cellular clock that synchronizes daily rhythms in mammals; circadian rhythms are the physiological processes that respond to a 24-hour cycle of light and dark and are present in most living things.

When given to diet-induced obese mice, these same small molecules decreased obesity by reducing fat mass and markedly improving cholesterol levels and hyperglycemia -- chronically high blood sugar levels that frequently lead to diabetes.

"The idea behind this research is that our circadian rhythms are coupled with metabolic processes and that you can modulate them pharmacologically," said Thomas Burris, a professor at Scripps Florida who led the study. "As it turns out, the effect of that modulation is surprisingly positive -- everything has been beneficial so far."

Burris stressed that these compounds were first generation -- the first to hit their targets in vivo with room for improvement as potential treatments. "In terms of therapeutics, this is really the first step," he said.

In the new study, the team identified and tested a pair of potent synthetic compounds that activate proteins called REV-ERBα and REV-ERBβ, which play an integral role in regulating the expression of core clock proteins that drive biological rhythms in activity and metabolism.

In the study, the scientists observed clear metabolic effects when the synthetic compounds were administered twice a day for 12 days. Animals displayed weight loss due to decreased fat mass with no changes in the amount of food they ate. The animals followed the human model of obesity closely, eating a standard Western diet of high fat, high sugar foods, yet still lost weight when given the compounds.

In one of the study's more striking findings, both synthetic compounds were shown to reduce cholesterol production. Cholesterol in the blood of treated animal models decreased 47 percent; triglycerides in the blood decreased 12 percent.

The circadian pattern of expression of a number of metabolic genes in the liver, skeletal muscle, and in fat tissue was also altered, resulting in increased energy expenditure, something of a surprise. In the study, the scientists observed a five percent increase in oxygen consumption, suggesting increased energy expenditure during the day and at night. However, these increases were not due to increased activity -- the animals displayed an overall 15 percent decrease in movement during those same time periods.

In addition to its impact on metabolism, the two compounds also affected the animals' activity during periods of light and darkness, suggesting that this class of compound may be useful for the treatment of sleep disorders, including the common problem of jet lag.

The first authors of the study, "Regulation of Circadian Behavior and Metabolism by Synthetic REV‐ERB Agonists," are Laura A. Solt and Yongjun Wang of Scripps Research. Other authors include Subhashis Banerjee, Travis Hughes, Douglas J. Kojetin, Thomas Lundasen, Youseung Shin, Jin Liu, Michael D. Cameron, Romain Noel, Andrew A. Butler, and Theodore M. Kamenecka of Scripps Research; and Seung‐Hee Yoo and Joseph S. Takahashi of the Howard Hughes Medical Institute and University of Texas Southwestern Medical Center.

The study was supported by the National Institutes of Health and the Howard Hughes Medical Institute.

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Link between fast food and depression confirmed

ScienceDaily (Mar. 30, 2012) — A new study along the same lines as its predecessors shows how eating fast food is linked to a greater risk of suffering from depression. This study has been published in the Public Health Nutrition journal

See Also:Health & MedicineNutritionMental Health ResearchDiet and Weight LossMind & BrainMental HealthDepressionDieting and Weight ControlLiving WellReferenceOily fishSouth Beach dietEating disorderFast food

According to a recent study headed by scientists from the University of Las Palmas de Gran Canaria and the University of Granada, eating commercial baked goods (fairy cakes, croissants, doughnuts, etc.) and fast food (hamburgers, hotdogs and pizza) is linked to depression.

Published in the Public Health Nutrition journal, the results reveal that consumers of fast food, compared to those who eat little or none, are 51% more likely to develop depression.

Furthermore, a dose-response relationship was observed. In other words this means that "the more fast food you consume, the greater the risk of depression," explains Almudena Sánchez-Villegas, lead author of the study.

The study demonstrates that those participants who eat the most fast food and commercial baked goods are more likely to be single, less active and have poor dietary habits, which include eating less fruit, nuts, fish, vegetables and olive oil. Smoking and working more than 45 hours per week are other prevalent characteristics of this group.

A long-term study

With regard to the consumption of commercial baked goods, the results are equally conclusive. "Even eating small quantities is linked to a significantly higher chance of developing depression," as the university researcher from the Canary Islands points out.

The study sample belonged to the SUN Project (University of Navarra Diet and Lifestyle Tracking Program). It consisted of 8,964 participants that had never been diagnosed with depression or taken antidepressants. They were assessed for an average of six months, and 493 were diagnosed with depression or started to take antidepressants.

This new data supports the results of the SUN project in 2011, which were published in the PLoS One journal. The project recorded 657 new cases of depression out of the 12,059 people analysed over more than six months. A 42% increase in the risk associated with fast food was found, which is lower than that found in the current study.

Sánchez-Villegas concludes that "although more studies are necessary, the intake of this type of food should be controlled because of its implications on both health (obesity, cardiovascular diseases) and mental well-being."

The impact of diet on mental health

Depression affects 121 million people worldwide. This figure makes it one of the main global causes of disability-adjusted life year. Further still, in countries with low and medium income it is the leading cause.

However, little is known about the role that diet plays in developing depressive disorders. Previous studies suggest that certain nutrients have a preventative role. These include group B vitamins, omega-3 fatty acids and olive oil. Furthermore, a healthy diet such as that enjoyed in the Mediterranean has been linked to a lower risk of developing depression.

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'Superinfected' Patients Give Clues to Fighting HIV

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Migraines likelier in men with impotence

Reuters – 2 hrs 0 mins ago NEW YORK (Reuters Health) - Men who have been diagnosed with erectile dysfunction are 63 percent more likely to also have had a diagnosis of migraine headaches than men without the sexual disorder, according to a new study from Taiwan.

Dr. Tobias Köhler of Southern Illinois University School of Medicine, who specializes in male sexual function and fertility, told Reuters Health this is the first he's heard of any such relationship between migraines and impotence.

"It's an interesting first recognition of the correlation, but by no means does it mean they're causally linked," said Köhler, who was not involved in the new research. It's not clear what might explain the link between erectile dysfunction (ED) and headache, although migraines have been linked to sexual dysfunction in women, the study authors note in the journal Cephalalgia.

But "no study to date has ever attempted to explore the association between migraine and ED," write Dr. Chao-Yuan Huang at National Taiwan University's College of Medicine and his colleagues.

It has been estimated that about 20 million men in the United States suffer from impotence.

The research team collected information on 23,000 men from a national database of insurance claims in Taiwan.

About 5,700 of the men had been diagnosed with erectile dysfunction, which is an inability to get or keep an erection.

Huang's group then compared ED patients to 17,000 similar men who had not sought treatment for impotence.

Among the men with ED, 245, or 4.25 percent, had previously been diagnosed with migraine headaches.

In the group without ED, 457 men, or 2.64 percent, had been diagnosed with migraines.

After the researchers took into account differences between the groups, including heart disease and diabetes, they found that ED patients were 1.63 times as likely to have had a previous migraine diagnosis as men in the other group.

Age seemed to make a difference.

Men in their 30s with erectile dysfunction were about twice as likely as men without it to have a diagnosis of migraines.

The researchers could only speculate as to why migraines are more common among men with erectile dysfunction.

"As it has been demonstrated that chronic pain can cause sexual dysfunction," the authors write, "one possible explanation for the association seen in this study may be the chronic pain associated with migraine headaches."

Köhler, who also represents the American Urological Association regarding sexual medicine, agreed that pain is a possible explanation.

"We definitely know that pain in general is bad for erections," he said.

The authors also offer up the brain chemical dopamine as a potential player, because it is thought to be involved in both migraine headaches and sexual function.

In addition, there's the possibility that the findings could be due to some other factor. For instance, men who see a doctor for migraines might be more likely to seek care for erection problems too, Huang's group notes.

Or it could be that the men diagnosed with migraines are taking medications that interfere with their sexual function, Köhler speculated.

Dr. Ege Serefoglu at Tulane University School of Medicine said that because this is the first stab at looking at the relationship between migraine and erectile dysfunction, the findings should be interpreted cautiously.

He added that the study was well conducted, but the results "need to be confirmed by other countries, other researchers, before we can really include migraine as a risk factor of erectile dysfunction or vice versa."

SOURCE: http://bit.ly/GFo00n Cephalalgia, online March 9, 2012.

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Migraines likelier in men with impotence

Reuters – 2 hrs 0 mins ago NEW YORK (Reuters Health) - Men who have been diagnosed with erectile dysfunction are 63 percent more likely to also have had a diagnosis of migraine headaches than men without the sexual disorder, according to a new study from Taiwan.

Dr. Tobias Köhler of Southern Illinois University School of Medicine, who specializes in male sexual function and fertility, told Reuters Health this is the first he's heard of any such relationship between migraines and impotence.

"It's an interesting first recognition of the correlation, but by no means does it mean they're causally linked," said Köhler, who was not involved in the new research. It's not clear what might explain the link between erectile dysfunction (ED) and headache, although migraines have been linked to sexual dysfunction in women, the study authors note in the journal Cephalalgia.

But "no study to date has ever attempted to explore the association between migraine and ED," write Dr. Chao-Yuan Huang at National Taiwan University's College of Medicine and his colleagues.

It has been estimated that about 20 million men in the United States suffer from impotence.

The research team collected information on 23,000 men from a national database of insurance claims in Taiwan.

About 5,700 of the men had been diagnosed with erectile dysfunction, which is an inability to get or keep an erection.

Huang's group then compared ED patients to 17,000 similar men who had not sought treatment for impotence.

Among the men with ED, 245, or 4.25 percent, had previously been diagnosed with migraine headaches.

In the group without ED, 457 men, or 2.64 percent, had been diagnosed with migraines.

After the researchers took into account differences between the groups, including heart disease and diabetes, they found that ED patients were 1.63 times as likely to have had a previous migraine diagnosis as men in the other group.

Age seemed to make a difference.

Men in their 30s with erectile dysfunction were about twice as likely as men without it to have a diagnosis of migraines.

The researchers could only speculate as to why migraines are more common among men with erectile dysfunction.

"As it has been demonstrated that chronic pain can cause sexual dysfunction," the authors write, "one possible explanation for the association seen in this study may be the chronic pain associated with migraine headaches."

Köhler, who also represents the American Urological Association regarding sexual medicine, agreed that pain is a possible explanation.

"We definitely know that pain in general is bad for erections," he said.

The authors also offer up the brain chemical dopamine as a potential player, because it is thought to be involved in both migraine headaches and sexual function.

In addition, there's the possibility that the findings could be due to some other factor. For instance, men who see a doctor for migraines might be more likely to seek care for erection problems too, Huang's group notes.

Or it could be that the men diagnosed with migraines are taking medications that interfere with their sexual function, Köhler speculated.

Dr. Ege Serefoglu at Tulane University School of Medicine said that because this is the first stab at looking at the relationship between migraine and erectile dysfunction, the findings should be interpreted cautiously.

He added that the study was well conducted, but the results "need to be confirmed by other countries, other researchers, before we can really include migraine as a risk factor of erectile dysfunction or vice versa."

SOURCE: http://bit.ly/GFo00n Cephalalgia, online March 9, 2012.

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Migraines likelier in men with impotence

Reuters – 2 hrs 0 mins ago NEW YORK (Reuters Health) - Men who have been diagnosed with erectile dysfunction are 63 percent more likely to also have had a diagnosis of migraine headaches than men without the sexual disorder, according to a new study from Taiwan.

Dr. Tobias Köhler of Southern Illinois University School of Medicine, who specializes in male sexual function and fertility, told Reuters Health this is the first he's heard of any such relationship between migraines and impotence.

"It's an interesting first recognition of the correlation, but by no means does it mean they're causally linked," said Köhler, who was not involved in the new research. It's not clear what might explain the link between erectile dysfunction (ED) and headache, although migraines have been linked to sexual dysfunction in women, the study authors note in the journal Cephalalgia.

But "no study to date has ever attempted to explore the association between migraine and ED," write Dr. Chao-Yuan Huang at National Taiwan University's College of Medicine and his colleagues.

It has been estimated that about 20 million men in the United States suffer from impotence.

The research team collected information on 23,000 men from a national database of insurance claims in Taiwan.

About 5,700 of the men had been diagnosed with erectile dysfunction, which is an inability to get or keep an erection.

Huang's group then compared ED patients to 17,000 similar men who had not sought treatment for impotence.

Among the men with ED, 245, or 4.25 percent, had previously been diagnosed with migraine headaches.

In the group without ED, 457 men, or 2.64 percent, had been diagnosed with migraines.

After the researchers took into account differences between the groups, including heart disease and diabetes, they found that ED patients were 1.63 times as likely to have had a previous migraine diagnosis as men in the other group.

Age seemed to make a difference.

Men in their 30s with erectile dysfunction were about twice as likely as men without it to have a diagnosis of migraines.

The researchers could only speculate as to why migraines are more common among men with erectile dysfunction.

"As it has been demonstrated that chronic pain can cause sexual dysfunction," the authors write, "one possible explanation for the association seen in this study may be the chronic pain associated with migraine headaches."

Köhler, who also represents the American Urological Association regarding sexual medicine, agreed that pain is a possible explanation.

"We definitely know that pain in general is bad for erections," he said.

The authors also offer up the brain chemical dopamine as a potential player, because it is thought to be involved in both migraine headaches and sexual function.

In addition, there's the possibility that the findings could be due to some other factor. For instance, men who see a doctor for migraines might be more likely to seek care for erection problems too, Huang's group notes.

Or it could be that the men diagnosed with migraines are taking medications that interfere with their sexual function, Köhler speculated.

Dr. Ege Serefoglu at Tulane University School of Medicine said that because this is the first stab at looking at the relationship between migraine and erectile dysfunction, the findings should be interpreted cautiously.

He added that the study was well conducted, but the results "need to be confirmed by other countries, other researchers, before we can really include migraine as a risk factor of erectile dysfunction or vice versa."

SOURCE: http://bit.ly/GFo00n Cephalalgia, online March 9, 2012.

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Migraines likelier in men with impotence

Reuters – 2 hrs 0 mins ago NEW YORK (Reuters Health) - Men who have been diagnosed with erectile dysfunction are 63 percent more likely to also have had a diagnosis of migraine headaches than men without the sexual disorder, according to a new study from Taiwan.

Dr. Tobias Köhler of Southern Illinois University School of Medicine, who specializes in male sexual function and fertility, told Reuters Health this is the first he's heard of any such relationship between migraines and impotence.

"It's an interesting first recognition of the correlation, but by no means does it mean they're causally linked," said Köhler, who was not involved in the new research. It's not clear what might explain the link between erectile dysfunction (ED) and headache, although migraines have been linked to sexual dysfunction in women, the study authors note in the journal Cephalalgia.

But "no study to date has ever attempted to explore the association between migraine and ED," write Dr. Chao-Yuan Huang at National Taiwan University's College of Medicine and his colleagues.

It has been estimated that about 20 million men in the United States suffer from impotence.

The research team collected information on 23,000 men from a national database of insurance claims in Taiwan.

About 5,700 of the men had been diagnosed with erectile dysfunction, which is an inability to get or keep an erection.

Huang's group then compared ED patients to 17,000 similar men who had not sought treatment for impotence.

Among the men with ED, 245, or 4.25 percent, had previously been diagnosed with migraine headaches.

In the group without ED, 457 men, or 2.64 percent, had been diagnosed with migraines.

After the researchers took into account differences between the groups, including heart disease and diabetes, they found that ED patients were 1.63 times as likely to have had a previous migraine diagnosis as men in the other group.

Age seemed to make a difference.

Men in their 30s with erectile dysfunction were about twice as likely as men without it to have a diagnosis of migraines.

The researchers could only speculate as to why migraines are more common among men with erectile dysfunction.

"As it has been demonstrated that chronic pain can cause sexual dysfunction," the authors write, "one possible explanation for the association seen in this study may be the chronic pain associated with migraine headaches."

Köhler, who also represents the American Urological Association regarding sexual medicine, agreed that pain is a possible explanation.

"We definitely know that pain in general is bad for erections," he said.

The authors also offer up the brain chemical dopamine as a potential player, because it is thought to be involved in both migraine headaches and sexual function.

In addition, there's the possibility that the findings could be due to some other factor. For instance, men who see a doctor for migraines might be more likely to seek care for erection problems too, Huang's group notes.

Or it could be that the men diagnosed with migraines are taking medications that interfere with their sexual function, Köhler speculated.

Dr. Ege Serefoglu at Tulane University School of Medicine said that because this is the first stab at looking at the relationship between migraine and erectile dysfunction, the findings should be interpreted cautiously.

He added that the study was well conducted, but the results "need to be confirmed by other countries, other researchers, before we can really include migraine as a risk factor of erectile dysfunction or vice versa."

SOURCE: http://bit.ly/GFo00n Cephalalgia, online March 9, 2012.

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CDC Helps Educators Identify Students with Autism Spectrum Disorders

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Blood clot risk higher in heavy women

Reuters – 1 hr 49 mins ago NEW YORK (Reuters Health) - Middle-aged women who are overweight or obese run a higher risk of potentially dangerous blood clots, especially after surgery, a large new study finds.

The research, which followed more than one million UK women, confirms a link between obesity and the risk of venous thromboembolism (VTE) -- blood clots in the veins, usually in the legs. If one of those clots breaks free and travels to the lungs, causing what's called a pulmonary embolism, it can prove fatal.

The findings also show that heavier women are more likely to end up needing surgery -- which is itself a major risk for VTE.

That's "not entirely unexpected," since obesity raises the risk of some medical conditions that could lead to surgery, said lead researcher Lianne Parkin, of the University of Otago in New Zealand.

"But as far as we know, our study is the first to directly examine the relationship between being overweight or obese and the likelihood of having an operation," Parkin told Reuters Health in an email.

The researchers found that for every 1,000 normal-weight women who had inpatient surgery over six years, about five developed a clot in a deep vein or a pulmonary embolism within 12 weeks of the operation.

Among overweight and obese women, that rate was seven per 1,000.

The risk of suffering a clot without surgery was far lower, but still relatively higher among heavier women.

Of normal-weight women, 0.1 out of every 1,000 developed a VTE during any 12-week period in which no surgery was done. The rate was 0.2 for every 1,000 overweight or obese women.

Overall, Parkin said, the risk of clots climbed in tandem with a woman's weight. "That suggests that the loss of even small amounts of weight is likely to be beneficial (in terms of reducing VTE risk) for women who are overweight or obese," she said.

The findings, which appear in the journal Circulation, are based on more than 1.1 million UK women who were 56 years old, on average, at the study's start. The researchers used hospital records and death certificates to track cases of VTE over six years.

During that time, 6,438 women were hospitalized for, or died from, a VTE -- with almost 1,900 forming a clot within 12 weeks of an operation. (That was out of more than 641,000 women who had at least one operation during the study period.)

Women who were overweight or obese were 22 percent more likely to need inpatient surgery versus their thinner peers.

That means more overweight women will face the chance of a surgery-related VTE, and their risk with any given surgery will be relatively higher compared with thin women.

According to Parkin's team, their figures probably underestimate the actual number of women who developed a VTE -- since clots in the leg veins may be detected and treated by a primary care doctor.

Those clots are almost always diagnosed because of symptoms, like pain in the calf, swelling in the ankle and foot and warmth over the affected area.

Treatment can include medication to keep a clot from growing or prevent new ones. Wearing compression stockings around the lower leg can also help prevent new clots.

According to Parkin, the best way for an overweight woman to cut the risk of a non-surgery-related VTE is to lose some weight. And that would come with "many other important health benefits," she pointed out.

"In addition to weight loss, though," Parkin added, "it is important to increase physical activity. Immobility is a risk factor for VTE, and overweight and obese people are often less physically active."

If you're facing surgery and have enough advance warning of it, shedding some weight is, again, a good idea, Parkin noted. In addition, you can ask your doctor what will be done to minimize any risk of post-surgery VTE.

There are different recommendations on how to help prevent surgery-related VTE, including the use of "blood-thinning" drugs. And those vary based on the type and duration of the surgery, Parkin said.

SOURCE: http://bit.ly/H2Xn9C Circulation, online March 6, 2012.

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