Female fat prejudice persists even after weight loss, study finds

ScienceDaily (May 29, 2012) — Overweight women may never escape the painful stigma of obesity - even after they have shed the pounds, new research suggests.

See Also:Health & MedicineObesityDiet and Weight LossMind & BrainDieting and Weight ControlNutrition ResearchScience & SocietyPublic HealthSportsReferenceBody mass indexOverweightGeneral fitness trainingNutrition and pregnancy

The study, by the University of Hawaii at Mānoa, The University of Manchester, and Monash University, examined whether anti-fat prejudice against women persisted even after they had lost significant weight and were now thin.

The researchers asked young men and women to read vignettes describing a woman who had either lost weight (70 pounds/32 kilograms) or had remained weight stable, and who was either currently obese or currently thin. Participants were then asked their opinions about this woman on a number of attributes, such as how attractive they found her, and their overall dislike for fat people.

The team found that participants in the study - published in the journal Obesity - expressed greater bias against obese people after reading about women who had lost weight than after reading about women who had remained weight stable, regardless of whether the weight-stable woman was thin or obese.

"We were surprised to find that currently thin women were viewed differently depending on their weight history," said Dr Janet Latner, study lead at the University of Hawaii at Mānoa, US. "Those who had been obese in the past were perceived as less attractive than those who had always been thin, despite having identical height and weight."

One of the more disturbing findings from the study, the researchers noted, was that negative attitudes towards obese people increase when participants are falsely told that body weight is easily controllable.

Co-author, Dr Kerry O'Brien, from the University of Manchester's School of Psychological Sciences and Monash University in Melbourne, Australia, said: "The message we often hear from society is that weight is highly controllable, but the best science in the obesity field at the moment suggests that one's physiology and genetics, as well as the food environment, are the really big players in one's weight status and weight-loss.

"Weight status actually appears rather uncontrollable, regardless of one's willpower, knowledge, and dedication. Yet many people who are perceived as 'fat' are struggling in vain to lose weight in order to escape this painful social stigma. We need to rethink our approaches to, and views of, weight and obesity."

The findings, say the authors, demonstrate that residual obesity stigma persists against individuals who have ever been obese, even when they have lost substantial amounts of weight. Obesity stigma is so powerful and enduring that it appears to even outlast the obesity itself.

Dr Latner added: "Descriptions of weight loss, such as those often promoted on television, may significantly worsen obesity stigma. Believing that obese people can easily lose weight may make individuals blame and dislike obese people more.

"The findings demonstrate that residual obesity stigma persists against individuals who have ever been obese, even when they have lost substantial amounts of weight. Obesity stigma is so powerful and enduring that it may even outlast the obesity itself. Given the great number of people who may be negatively affected by this prejudice, obesity discrimination clearly needs to be reduced on a societal level."

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Fatty acid found in fish prevents age-related vision loss, study suggests

ScienceDaily (May 30, 2012) — An omega-3 fatty acid found in fish, known as DHA, prevented age-related vision loss in lab tests, according to recent medical research from the University of Alberta.

See Also:Health & MedicineHealthy AgingEye CarePersonalized MedicineMind & BrainPerceptionSchizophreniaDementiaReferenceOily fishVisual fieldVitreous humourPeripheral vision

Yves Sauvé, a researcher in the Faculty of Medicine & Dentistry, and his team discovered that lab models fed DHA did not accumulate a toxic molecule at the back of the eyes. The toxin normally builds up in the retina with age and causes vision loss.

"This discovery could result in a very broad therapeutic use," says Sauvé, whose work was recently published in the peer-reviewed journal Investigative Ophthalmology & Visual Science.

"In normal aging, this toxin increases twofold as we age. But in lab tests, there was no increase in this toxin whatsoever. This has never been demonstrated before -- that supplementing the diet with DHA could make this kind of difference."

The team recently started another study, looking at people who have age-related macular degeneration, a condition that results in loss of central vision and is the main cause of blindness in people over the age of 50. The researchers will look for DNA markers in the blood of study participants. The team wants to determine whether participants with certain genetic markers will respond better to increasing amounts of DHA in their diet, and if so, why.

Sauvé is a researcher in the departments of ophthalmology and physiology at the U of A.

Various organizations funded the research; the primary funder was the Canadian Institutes of Health Research.

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Compounds dramatically alter biological clock and lead to weight loss, animal study suggests

ScienceDaily (Mar. 29, 2012) — Scientists from the Florida campus of The Scripps Research Institute have synthesized a pair of small molecules that dramatically alter the core biological clock in animal models, highlighting the compounds' potential effectiveness in treating a remarkable range of disorders -- including obesity, diabetes, high cholesterol, and serious sleep disorders.

See Also:Health & MedicineDiet and Weight LossObesityMind & BrainDieting and Weight ControlInsomniaPlants & AnimalsMiceAgriculture and FoodReferenceCircadian rhythmCircadian rhythm sleep disorderJet lagDiabetes mellitus type 2

The study was published on March 29, 2012, in an advance, online edition of the journal Nature.

The study showed that when administered in animal models the synthetic small molecules altered circadian rhythm and the pattern of core clock gene expression in the brain's hypothalamus, the site of the master cellular clock that synchronizes daily rhythms in mammals; circadian rhythms are the physiological processes that respond to a 24-hour cycle of light and dark and are present in most living things.

When given to diet-induced obese mice, these same small molecules decreased obesity by reducing fat mass and markedly improving cholesterol levels and hyperglycemia -- chronically high blood sugar levels that frequently lead to diabetes.

"The idea behind this research is that our circadian rhythms are coupled with metabolic processes and that you can modulate them pharmacologically," said Thomas Burris, a professor at Scripps Florida who led the study. "As it turns out, the effect of that modulation is surprisingly positive -- everything has been beneficial so far."

Burris stressed that these compounds were first generation -- the first to hit their targets in vivo with room for improvement as potential treatments. "In terms of therapeutics, this is really the first step," he said.

In the new study, the team identified and tested a pair of potent synthetic compounds that activate proteins called REV-ERBα and REV-ERBβ, which play an integral role in regulating the expression of core clock proteins that drive biological rhythms in activity and metabolism.

In the study, the scientists observed clear metabolic effects when the synthetic compounds were administered twice a day for 12 days. Animals displayed weight loss due to decreased fat mass with no changes in the amount of food they ate. The animals followed the human model of obesity closely, eating a standard Western diet of high fat, high sugar foods, yet still lost weight when given the compounds.

In one of the study's more striking findings, both synthetic compounds were shown to reduce cholesterol production. Cholesterol in the blood of treated animal models decreased 47 percent; triglycerides in the blood decreased 12 percent.

The circadian pattern of expression of a number of metabolic genes in the liver, skeletal muscle, and in fat tissue was also altered, resulting in increased energy expenditure, something of a surprise. In the study, the scientists observed a five percent increase in oxygen consumption, suggesting increased energy expenditure during the day and at night. However, these increases were not due to increased activity -- the animals displayed an overall 15 percent decrease in movement during those same time periods.

In addition to its impact on metabolism, the two compounds also affected the animals' activity during periods of light and darkness, suggesting that this class of compound may be useful for the treatment of sleep disorders, including the common problem of jet lag.

The first authors of the study, "Regulation of Circadian Behavior and Metabolism by Synthetic REV‐ERB Agonists," are Laura A. Solt and Yongjun Wang of Scripps Research. Other authors include Subhashis Banerjee, Travis Hughes, Douglas J. Kojetin, Thomas Lundasen, Youseung Shin, Jin Liu, Michael D. Cameron, Romain Noel, Andrew A. Butler, and Theodore M. Kamenecka of Scripps Research; and Seung‐Hee Yoo and Joseph S. Takahashi of the Howard Hughes Medical Institute and University of Texas Southwestern Medical Center.

The study was supported by the National Institutes of Health and the Howard Hughes Medical Institute.

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