Pre-op Treatments Boost Survival for Esophageal Cancer Patients: Study

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Chronic Heartburn May Boost Risk for Esophageal Cancer

HealthDay – Fri, May 18, 2012 FRIDAY, May 18 (HealthDay News) -- Inflammation caused by chronic heartburn may increase the risk of esophageal cancer, a new study finds.

The condition -- formally known as gastroesophageal reflux disease (GERD) -- occurs when a muscle at the end of the esophagus doesn't close properly, allowing stomach contents to leak back into the esophagus and irritate it.

GERD can lead to changes in the tissue lining the esophagus, a condition called Barrett's esophagus, often a precursor to esophageal cancer.

In the study, researchers looked at nearly 34,000 GERD patients in Denmark and found that 77 percent had inflammation of the lining of the esophagus, a condition called erosive reflux disease. During an average follow-up time of 7.4 years, 0.11 percent of patients developed esophageal cancer.

The incidence of esophageal cancer among GERD patients with erosive disease was much higher than that of the general population, the team noted.

In contrast, esophageal cancer was diagnosed in only 0.01 percent of GERD patients without erosive disease after 4.5 years of follow-up.

The study appears in the May issue of the journal Clinical Gastroenterology and Hepatology.

"Our research shows that damage to the esophageal lining ... is important in the progression from normal cells to cancer, and Barrett's esophagus is likely to be an intermediate step," lead author Dr. Rune Erichsen, of Aarhus University Hospital in Denmark, said in a journal news release.

The incidence of esophageal cancer in the United States and Europe has increased dramatically in the past three decades. About 10,000 new cases of esophageal cancer are diagnosed each year in the United States.

Although the study identified an association between inflammation caused by GERD and increased incidence of esophageal cancer, it could not prove a cause-and-effect relationship.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about GERD.

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Esophageal Cancer Surgery Can Leave Lingering Health Problems, Study Says

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Body mass index not linked to post-surgical complications, survival in esophageal adenocarcinoma, study suggests

ScienceDaily (Mar. 28, 2012) — Researchers at Moffitt Cancer Center in Tampa, Fla., have found -- contrary to previous studies linking inferior outcomes in patients with gastrointestinal malignancies to higher body mass index (BMI) -- that in their study of BMI and negative outcomes, there was no such link. They concluded that BMI was not associated with either surgical complications or esophageal cancer patient survival.

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Their study was published in the current online issue of the Journal of Gastrointestinal Surgery, published by the Society for Surgery of the Alimentary Tract.

"The incidence of esophageal cancer in North America is rising," said study co-author Kenneth L. Meredith, M.D., assistant member at Moffitt and chief of the Esophagogastric Oncology Section. "Corresponding to that rise, there has been a dramatic rise in overweight and obese people as defined by the World Health Organization's guidelines indicating those having a BMI of 25 to 29.9 as being overweight and those who are obese as having a BMI of over 30."

According to the researchers, the increase in obesity and the increase in esophageal cancer has been linked, as has obesity been similarly linked with other kinds of cancers. Obesity is recognized as a risk factor for esophageal cancer. What remains in question, however, is whether a high BMI affects post-surgical complications and overall survival among esophageal cancer patients who have been treated with chemotherapy, radiation and surgery.

"The correlation of obesity with surgical risks and postoperative survival is more important given the rise in obesity rates, yet more clarity on potential correlation is needed," said Meredith. "The literature shows mixed study results."

In their paper, the authors cited a number of studies that correlated lower BMI with better outcomes for a variety of cancers as well as studies that found no prognostic significance correlating higher BMI with poorer outcomes.

Because of the prevailing belief that patients with a high BMI tend to have more surgical complications as compared to normal weight patients, the Moffitt researchers examined esophageal cancer patient data on BMI for links to surgical risk and postoperative survival, especially for those patients with high BMI.

Their study included 303 esophageal cancer patients treated with chemotherapy, radiation and surgery who were stratified by their BMI to include those with BMIs less than 25 to greater than 35. The only demographic differences were in gender, with a higher proportion of males in the BMI 25 to 30 group.

"Our study demonstrated no significant differences in overall survival or disease-free survival in relation to BMI for patients with esophageal adenocarcinoma who underwent surgery after prior treatment with chemotherapy and radiation," said Meredith. "Additionally, there were no differences in perioperative complications or mortality associated with BMI. In short, our data failed to demonstrate a link between BMI and surgical outcome."

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