Gamma Tocotrienol Weakens and Kills Prostate Cancer Cells

Protection of both women’s and men’s sexual organs is important for survival and quality of life.  Previously, I reported on exciting research relating to gamma tocotrienol Specialized form of vitamin E. Powerful antioxidant showing positive benefits for cholesterol, cardiovascular, neurological health and cancer risk reduction. and breast cancer in my article, Gamma Tocotrienol for Breast Cancer Prevention and Treatment.  New research now shows that gamma tocotrienol Specialized form of vitamin E. Powerful antioxidant showing positive benefits for cholesterol, cardiovascular, neurological health and cancer risk reduction. may be quite helpful for prostate cancer prevention and treatment.

Gamma tocotrienol Specialized form of vitamin E. Powerful antioxidant showing positive benefits for cholesterol, cardiovascular, neurological health and cancer risk reduction. is one of the best nutrients for managing cholesterol because it can help lower cholesterol in a healthy way.  Interestingly, this nutrient has a different effect on cholesterol in cancer cells.  Cancer cells try to use cholesterol to fortify the cell walls so they are stronger.  Gamma tocotrienols can tell the difference between healthy cells and cancer cells and act to crumble the cholesterol structure of the cancer cell, as I explained in an earlier article, Tocotrienols: Twenty Years of Dazzling Cardiovascular and Cancer Research.

The new research demonstrated that prostate cancer cells have a high level of gene activity called Sterol-Regulatory Element Binding Protein isoform 2 (SREBP-2).  This gene signal recruits extra cholesterol to the cancer, which is used to make stronger cell membranes.  Researchers showed that cancer cell survival was dependent on the SREBP-2 gene doing its job at a high level of function.  Then they showed that gamma tocotrienol Specialized form of vitamin E. Powerful antioxidant showing positive benefits for cholesterol, cardiovascular, neurological health and cancer risk reduction. directly knocks down this gene signal in prostate cancer cells, leading to prostate cancer cell death.  The prostate cancer cell destructive activity of tocotrienols does not happen to normal healthy prostate cells, meaning tocotrienols can tell friend from foe and act accordingly.

The implications of this study are profound and will require human studies to demonstrate dose and effectiveness.  Nevertheless, the lack of toxicity to human cells means there is very little reason for any man not to use them as part of a plan to prevent or help treat prostate issues.  Furthermore, such a nutrient will be supportive of just about any medical treatment.  Since gamma tocotrienol Specialized form of vitamin E. Powerful antioxidant showing positive benefits for cholesterol, cardiovascular, neurological health and cancer risk reduction. weakens cancer cells, those cells are now less resistant to cancer drugs, which has been demonstrated numerous times.

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DHA Inhibits Prostate Cancer

Italian researchers have demonstrated for the first time that DHA Docosahexaenoic acid Essential omega 3 fatty acid integral to the health of all cell membranes, nerve and brain function. Must be gotten through the diet via cold water oceanic fish or some very limited plant sources or taken as a supplement. directly inhibits two of the most important tumor promoting activities involved with prostate cancer progression.  This study means that all men over the age of 50 should have a high level of DHA Docosahexaenoic acid Essential omega 3 fatty acid integral to the health of all cell membranes, nerve and brain function. Must be gotten through the diet via cold water oceanic fish or some very limited plant sources or taken as a supplement. intake, at least 1 gram per day of DHA Docosahexaenoic acid Essential omega 3 fatty acid integral to the health of all cell membranes, nerve and brain function. Must be gotten through the diet via cold water oceanic fish or some very limited plant sources or taken as a supplement..

DHA Docosahexaenoic acid Essential omega 3 fatty acid integral to the health of all cell membranes, nerve and brain function. Must be gotten through the diet via cold water oceanic fish or some very limited plant sources or taken as a supplement. is needed by every cell of your body to function normally.  This new study documents how DHA Docosahexaenoic acid Essential omega 3 fatty acid integral to the health of all cell membranes, nerve and brain function. Must be gotten through the diet via cold water oceanic fish or some very limited plant sources or taken as a supplement. directly disrupts the process of prostate cancer growth – a rather dramatic finding.  DHA Docosahexaenoic acid Essential omega 3 fatty acid integral to the health of all cell membranes, nerve and brain function. Must be gotten through the diet via cold water oceanic fish or some very limited plant sources or taken as a supplement. blocks replication and invasiveness, which is very good news for men.

There are a lot of reasons for men to load up on DHA Docosahexaenoic acid Essential omega 3 fatty acid integral to the health of all cell membranes, nerve and brain function. Must be gotten through the diet via cold water oceanic fish or some very limited plant sources or taken as a supplement. including heart health, brain function, metabolism, and sex hormone function.  This study provides solid science to use DHA Docosahexaenoic acid Essential omega 3 fatty acid integral to the health of all cell membranes, nerve and brain function. Must be gotten through the diet via cold water oceanic fish or some very limited plant sources or taken as a supplement. for prostate cancer prevention and, when needed, as a part of a prostate cancer treatment protocol (in conjunction with appropriate medical options).

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Task Force Calls Routine Prostate Cancer Tests Unnecessary

This story comes from the Yahoo! Contributor Network, where individuals publish their unique perspectives on some of the world’s most popular websites.Do you have a story to tell? Become a Yahoo! contributor

When it comes to middle age, routine prostate cancer screening tests are to men what mammograms are to women. However, a federal task force believes administering the prostate-specific antigen (PSA) test on a routine basis to healthy middle-aged men is a waste of time.

According to the U.S. Preventive Services Task Force (USPSTF), the PSA test might cause more harm than good. The task force is an independent group authorized by Congress in 1984 and supported by the U.S. Department of Human Services. Its 16 volunteer members represent various medical fields. Its job: improving the health of Americans by making recommendations about clinical preventive services like screenings, medications, and counseling.

The task force says that prostate cancer is the most frequently diagnosed non-skin cancer in U.S. men. The lifetime risk of a diagnosis is an estimated 15.9 percent. The likelihood of actually dying of this type of cancer is less than 3 percent, and the disease is rare before age 50. Around 70 percent of the deaths attributed to it occur in men older than 75.

The USPSTF findings suggest that routine PSA testing would help save the life of just one man out of 1,000. According to the Washington Post, the recommendation concludes that for every patient saved by a PSA test, one will develop a serious blood clot, and two will experience heart attacks. Another 40 will experience impotence or incontinence after unnecessary treatment. However, patients with urinary symptoms such as pain or trouble urinating might benefit from the screening, the USPSTF concluded. Urologists expressed a very negative reaction to the recommendations.

A PSA test doesn't actually detect cancer. It finds a protein manufactured by the prostate. A number of benign prostate problems can cause elevated numbers of protein. This might mean a false positive leading to biopsies and other testing.

Most doctors don't rely solely on a PSA test when a patient has symptoms that might point to prostate cancer. A man who has reached his forties might also experience a digital rectal exam, ultrasound, and/or a transrectal biopsy of the prostate, says the Mayo Clinic.

Results of a PSA test with elevated numbers struck home last year. A family member with a history of low numbers went in for another routine screening. The PSA numbers had increased significantly but were still within normal range. Told to return in six months, he showed up, non-symptomatic, for the second blood test on schedule. The numbers were a bit higher but still within normal range.

Two weeks later, he underwent outpatient biopsies. He likened the procedure to a dozen cookie cutters powered by a pneumatic drill. He bled for days and experienced pain for weeks. There was no cancer. He has no plans to undergo additional routine prostate cancer screening.

Vonda J. Sines has published thousands of print and online articles. She specializes in health and medical topics, with a particular interest in diseases and other conditions that affect quality of life.

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Advanced Prostate Cancer Drug May Help at Earlier Stage

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Prostate drug limits love life

Q. I am at my wits’ end. I’ve been taking Prempro for hot flashes. Now my doctor wants me to stop because of cancer concerns. Whenever I quit, though, the hot flashes return worse than ever.

My friends swear by bioidentical hormones, but my doctor says that they have not been proven any safer than Prempro. She wants me to try Effexor XR, but I am not ready to take an antidepressant for hot flashes. Help!

A. Your doctor may be reacting

to a study reported at the American Association for Cancer Research this spring. The Nurses’ Health Study acquired data from 60,000 women over several decades. Those who took postmenopausal estrogen were at greater risk of breast cancer. Progesterone increased the risk even more.

Bioidentical hormones have not been tested so thoroughly, so your doctor is erring on the side of caution. For more information on dealing with hot flashes and vaginal dryness, plus the pros and cons of hormones, we are sending you our Guide to Menopause. In it we discuss nondrug approaches such as Pycnogenol and black cohosh. Anyone who would like a copy, please send $3 in check or money order with a long (No. 10), stamped (65 cents), self-addressed envelope to: Graedons’ People’s Pharmacy, No. W-50, P.O. Box 52027, Durham, NC 27717-2027. It also can be downloaded for $2 from our website: www.peoplespharmacy.com.

Although antidepressants like fluoxetine (Sarafem), venlafaxine (Effexor) and paroxetine (Paxil) may ease hot flashes, stopping such drugs suddenly can cause unpleasant withdrawal symptoms, including dizziness, headache and hot flashes.

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Warren Buffett Has Early Stage Prostate Cancer

HealthDay – 30 mins ago WEDNESDAY, April 18 (HealthDay News) -- U.S. billionaire investor Warren Buffett says he has prostate cancer and will undergo radiation treatment in the coming months.

The 81-year-old chairman and chief executive of Berkshire Hathaway Inc. said in a letter to investors on Tuesday that he has stage 1 cancer, an early form of the disease that is treatable.

"The good news is that I've been told by my doctors that my condition is not remotely life-threatening or even debilitating in any meaningful way," Buffett said.

After receiving the diagnosis last Wednesday, Buffett said he had other tests that "showed no incidence of cancer elsewhere in my body."

In his letter, Buffett said he expects to begin two months of daily radiation treatment in mid-July. It will restrict his travel, "but will not otherwise change my daily routine."

He added that, "I discovered the cancer because my PSA level

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Pricier therapy no better for early prostate cancer

Reuters – 1 hr 49 mins ago NEW YORK (Reuters Health) - A new study suggests that expensive, high-tech proton beam radiation doesn't do any more for men with prostate cancer than the most commonly-used option.

Proton beam radiation, heavily promoted by facilities that perform the treatment, also came with a higher risk of certain side effects compared to intensity-modulated radiation therapy (IMRT), researchers found.

"This paper is the strongest evidence yet that proton beam (therapy) is not only not better, but probably not as good as IMRT," said Dr. Matthew Cooperberg, a urologist from the University of California, San Francisco, who didn't participate in the new research.

The findings suggest that men have multiple radiation options when it comes to treating early, localized prostate cancer.

Though not covered in the new study, their options also include surgery -- or getting no treatment at all and waiting to see how the disease progresses, researchers said.

Dr. Ronald Chen of the University of North Carolina at Chapel Hill and his colleagues used data from a nationwide cancer registry covering treatment records for men insured by Medicare who were diagnosed with prostate cancer starting in 2000.

At that time, less than one percent of prostate cancers that hadn't spread beyond the gland were treated with IMRT, a minimally-invasive treatment meant to limit damage to the surrounding organs. The rest were treated conformal radiation, the previous standard of care.

By 2008, almost 96 percent of men got the high-dose, targeted radiation.

Intensity-modulated radiation was tied to an approximately 10 to 20 percent lower risk of stomach problems and hip fractures compared to conformal radiation therapy, which exposes more organs around the prostate to radiation. But it also came with a 12 percent higher risk of erectile dysfunction.

Over the course of each year after radiation, 2.5 percent of men who'd received IMRT needed more cancer treatment -- suggesting their disease came back -- compared to 3.1 percent of men in the traditional-radiation group.

That was based on records of close to 13,000 men age 66 and older.

In a smaller analysis, Medicare patients who got proton beam therapy, the most high-tech type of radiation offered, didn't fare much better or worse than those who had IMRT -- except that proton-treated men had more stomach-related side effects.

HUNDREDS OF MILLIONS IN COSTS

The use of both of those technologies has driven up the cost of prostate cancer treatment by hundreds of millions of dollars, the researchers wrote in the Journal of the American Medical Association.

But with conformal radiation fading from popularity, patients' radiation choice now tends to come down to IMRT versus proton therapy -- which is available at far fewer cancer centers because of the technology required.

Researchers said that proton beam facilities can cost $100 million or more to build. A round of proton beam radiation treatment costs insurers up to $100,000 per patient, while IMRT is billed at about $50,000.

"Here we have more expensive therapy that is not proven to give a better outcome," said Dr. Eric Klein, a prostate cancer researcher at the Cleveland Clinic, who didn't take part in the new study.

Researchers agreed that policymakers, including those that decide how much Medicare will pay for various treatments, should reevaluate the evidence for cancer outcomes -- including whether proton beam therapy is worth its hefty price tag.

"There's a trend in this country of adopting newer, costly, promising treatments, without very much evidence to prove they're better," Chen told Reuters Health.

"What our data provides the patients is evidence that IMRT is a good prostate cancer treatment," he said. Until more rigorous studies are available, "That's the type of radiation that they should seek."

WATCHFUL WAITING?

Another perfectly good option for men with early prostate cancer is not to get treatment at all, but to wait and see whether the cancer grows or doesn't cause any harm, researchers said.

"Many men with early disease, especially men who are older, likely don't need treatment," said Dr. W. Robert Lee, a radiation oncologist at the Duke University School of Medicine in Durham who wasn't involved in the new study.

"Active surveillance really plays a very important role," he told Reuters Health.

Cooperberg told Reuters Health that if men find their doctor pushing one treatment option, especially if it's a high-tech radiation option, they should seek outside opinions and think about their priorities -- in terms of what side effects they can put up with and the chance of needing more serious treatment.

"Prostate cancer is very much a disease of options," Lee said.

SOURCE: http://bit.ly/hwxtTL Journal of the American Medical Association, online April 17, 2012.

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New Scanning Technology Might Help Guide Prostate Cancer Care

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