Milk ingredient does a waistline good

ScienceDaily (June 5, 2012) — A natural ingredient found in milk can protect against obesity even as mice continue to enjoy diets that are high in fat. The researchers who report their findings in the June Cell Metabolism, a Cell Press publication, liken this milk ingredient to a new kind of vitamin.

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"This is present in what we've all been eating since day one," says Johan Auwerx of École Polytechnique Fédérale de Lausanne.

The researchers identified this ingredient, known as nicotinamide riboside, as they were searching for alternative ways to boost the well-known gene SIRT1, which comes with benefits for both metabolism and longevity. One way to do that is to target SIRT1 directly, as the red wine ingredient resveratrol appears to do, at least at some doses.

Auwerx's team suspected there might be a simpler way to go about it, by boosting levels of one of SIRT1's molecular sidekicks, the cofactor NAD

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Herbal Remedy Ingredient Tied to Cancer, Kidney Failure

HealthDay – 43 mins ago THURSDAY, April 12 (HealthDay News) -- A toxic component of a plant used in certain types of herbal remedies can cause kidney failure and upper urinary tract cancer, researchers warn.

Aristolochic acid is found in Aristolochia herbal remedies, which have been used for centuries and still are used in many countries.

This study of 151 patients with upper urinary tract cancer in Taiwan concluded that aristolochic acid is a primary contributor to the incidence of this cancer in Taiwan, where the incidence is the highest reported anywhere in the world and where Aristolochia herbal remedies are widely used.

The researchers found that 83 percent of the patients had evidence in their kidneys of DNA changes that are related to the plant toxin and associated with the development of cancer.

"We believe our latest research highlights the importance of a long-overlooked disease that affects many individuals in Taiwan, and, by extension, in China and other countries worldwide, where Aristolochia herbal remedies traditionally have been used for medicinal purposes," Dr. Arthur Grollman, a professor of pharmacological sciences at Stony Brook University School of Medicine, in New York, said in a university news release.

In previous research, Grollman and his colleagues linked the ingestion of Aristolochia clematitis (commonly known as birthwort) to widespread kidney disease in the Balkans.

The findings of the studies show that public health officials need to take action to stop kidney damage and upper urinary tract cancer related to aristolochic acid, Grollman said.

The study was published online April 9 in the journal Proceedings of the National Academy of Sciences.

More information

The U.S. National Kidney Disease Education Program explains how to keep your kidneys healthy.

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