Thursday, July 12, 2012

Diet, Weight Loss Ease Menopause Symptoms: Study

HealthDay – 1 hr 2 mins ago WEDNESDAY, July 11 (HealthDay News) -- Menopausal women who lose weight eating a low-fat diet rich in fruits and vegetables could reduce or eliminate their hot flashes and night sweats, a large new study suggests.

One reason the researchers looked at weight loss as a way of dealing with menopausal symptoms was because of long-standing research linking hormone-replacement therapy to heart disease and breast cancer.

"We wanted to see if this could be an alternative to hormone therapy," said lead researcher Candyce Kroenke, a research scientist at Kaiser Permanente's Northern California Division of Research in Oakland.

"Indeed, women who lost weight in the context of this healthier diet -- decreasing fat, increasing whole grains, fruits and vegetables -- were significantly more likely to reduce or eliminate symptoms," she added.

Reduced hot flashes and night sweats, the key menopausal symptoms, were seen in both overweight and normal-weight women who lost weight, Kroenke noted.

And the reason for that is fairly simple, she said: Fat tends to retain heat and losing weight helps the body dissipate heat more easily.

The report, which was published July 11 in the online edition of Menopause, involved data on more than 17,000 women who took part in the Women's Health Initiative study.

The women with menopausal symptoms who were on a low-fat diet rich in whole grains, fruits and vegetables, who were not taking hormone-replacement therapy and who lost at least 10 pounds in a year were more likely to see night sweats and hot flashes reduced or disappear after a year than did women who maintained their weight (the "control" group), the researchers found.

Dr. Jennifer Wu, an obstetrician/gynecologist at Lenox Hill Hospital in New York City, commented that "this definitely goes along with the idea that good diet and exercise and losing weight contribute to general health."

And, she added, "It's a quick and easy fix for hot flashes and night sweats."

Wu noted that doctors are still reluctant to offer hormone-replacement therapy even though it works. "This is a low-risk fix," she said.

"I think it will work for some patients, and patients may only get a partial relief of their symptoms, but any help is good," Wu pointed out.

"Diet and weight loss is a healthy habit that will hopefully help menopausal symptoms. There is very little downside to doing it," she added.

Another expert agreed.

"Adopting a healthy diet is always a good idea," said Samantha Heller, a nutritionist, exercise physiologist and clinical nutrition coordinator at the Center for Cancer Care at Griffin Hospital in Derby, Conn.

"Healthy foods, including vegetables, soy, whole grains, legumes, nuts and fruits, decrease the risk of many chronic diseases and can improve health and well-being considerably. In this case, along with weight loss of 10 pounds or 10 percent of body weight, women who made healthy dietary changes tended to have decreased symptoms of hot flashes and night sweats," Heller noted.

"This study also highlights the positive effect of ongoing nutrition education by registered dietitians," she added. "Women in the intervention group, who were counseled by registered dietitians, were three times more likely to lose weight than women in the control group. A big factor in unsuccessful weight loss attempts is people not knowing how or where to begin. Nutrition counseling takes the guesswork out of creating a healthy lifestyle and helps motivate and empower people to stay on track."

The research was published just days after a coalition of leading medical groups concluded in a joint statement that hormone-replacement therapy can be useful and safe for many women suffering from the symptoms of menopause.

The coalition includes 15 medical groups, including the North American Menopause Society, the American Society for Reproductive Medicine, the Endocrine Society and the American Academy of Family Physicians.

More information

For more information on menopause, visit the U.S. National Library of Medicine.



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Timeline Detected for Rare, Early Alzheimer's

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HIV Drug May Prevent Bone Marrow Transplant Complication

HealthDay – 1 hr 2 mins ago WEDNESDAY, July 11 (HealthDay News) -- An HIV drug significantly reduced the risk of graft-versus-host disease, an all-too-common complication in blood cancer patients following bone marrow transplants, new research finds.

Bone marrow is the spongy tissue inside the bones that contains immature cells, or stem cells. In an "allogeneic" bone marrow transplantation, also called a stem cell transplant, a patient's own stem cells and immune system are wiped out by chemotherapy and radiation. Then, the patient receives the transplant, or bone marrow, from a closely matched donor.

The treatment is used for several types of blood cancers, including lymphoma and leukemia.

But a common complication of a bone marrow transplant is graft-versus-host disease. It occurs when transplanted immune cells attack patients' healthy tissue, a complication that can be minor or life-threatening.

"Graft-versus-host disease affecting the skin, liver, gut and other organs is a dreaded complication of allogeneic stem cell transplantation either from a related or unrelated donor," said one expert, Dr. Jasmine Zain of NYU Langone Medical Center in New York City. "The rates are 35 percent with related donors and up to 57 percent by day 100, even in reduced-intensity transplants," added Zain, who is director of the Bone Marrow Transplant Program and assistant professor in the division of hematologic malignancies and medical oncology at the center.

The study was conducted by a team at the University of Pennsylvania's Perelman School of Medicine and included 38 patients with several types of blood cancers. The cancers included acute myeloid leukemia, myelodysplastic syndrome, lymphoma and myelofibrosis. All of the patients were given the drugs tacrolimus and methotrexate, which suppress the immune system and are a standard treatment to prevent graft-versus-host disease.

The patients were also given a 33-day course of the HIV drug, maraviroc, beginning two days before their transplant.

None of the patients treated with maraviroc developed graft-versus-host disease in the gut or liver within the first 100 days after their transplant. The liver and gut are the most serious locations for the complication, the researchers noted.

After six months, 6 percent of these transplant patients developed severe graft-versus-host disease compared to 22 percent of a group of similar patients who weren't treated with the HIV drug.

In addition, fewer in the group given the HIV drug developed graft-versus-host disease in their liver or gut compared to those given the standard treatment.

One year following transplant, about 15 percent of patients given the HIV drug developed severe graft-versus-host disease compared to 29 percent of patients who received standard therapy.

The study was published in the July 11 edition of the New England Journal of Medicine.

Researchers explained that the HIV drug redirects these immune cells without having to suppress patients' immune systems. Because their immune systems aren't compromised by the drug, patients should be less vulnerable to infections and to a relapse of their cancer.

"It appears that our new approach allows us to prevent some patients from developing

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Scientists Pinpoint Antibody That May Be Specific to MS Patients

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Little change in Dutch euthanasia post-legality

The frequency of doctor-assisted euthanasia in the Netherlands has changed little since the longstanding practice was legalized in 2002, according to a new study.

A summary published Wednesday on The Lancet magazine's website said that "in 2010, of all deaths in the Netherlands, 2.8 percent were the result of euthanasia. This is higher than the 1.7 percent in 2005, but comparable with (levels seen) in 2001 and 1995."

Under Dutch law, a person who asks to die may be administered a lethal mixture of sedatives and muscle relaxants if two doctors agree he or she is suffering "unbearable" pain with no prospect for recovery. Most cases involve cancer victims.

The Lancet study used data from the country's death registry and sent confidential questionnaires to doctors, extrapolating results to represent a cross-section of deaths in different social, medical and geographical areas. Researchers used the same methodology as in previous studies in 1990, 1995, 2001 and 2005.

Dutch doctors are also required to report all euthanasia cases on a non-confidential basis to the country's Euthanasia Commission, but that yields numbers that are widely believed to underreport the total number of euthanasia cases in the country.

All cases sent to the Euthanasia Commission are reviewed by a panel of experts, and some cases each year lead to official sanctions for doctors who fail to follow the rules, or even criminal prosecutions in a handful of cases.

According to commission data, there were 3,136 euthanasia cases in 2010, out of 136,000 deaths countrywide recorded by the Central Bureau for Statistics. That suggests a euthanasia rate of about 2.3 percent, less than the 2.8 percent found in the Lancet study. The total Dutch population is around 16.3 million.

"In the Netherlands, the euthanasia law resulted in a relatively transparent practice," wrote the Lancet study's lead author Bregje Onwuteaka-Philipsen. "Although translating these results to other countries is not straightforward, they can inform the debate on legalization of assisted dying in other countries."

One other noteworthy finding of the Lancet study was that the number of cases of "palliative sedation"

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Wildland firefighters win federal health benefits

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Last drugs standing: Key Alzheimer results coming

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Developing nations to get $2.6 bln for family planning

"British Prime Minister David Cameron (L) and Melinda Gates (R) speak with delegates during the London Summit on Family Planning in central London. Rich nations and the Bill and Melinda Gates Foundation said they had pledged more than 2.6 billion dollars towards family planning in developing countries at a summit in London Wednesday. (AFP Photo/Carl Court)" title

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In US, painkiller abusers turning to heroin: research

"Ever since the popular painkiller pill OxyContin became harder to crush into powder two years ago, many US drug abusers have turned to heroin instead, researchers said Wednesday. (AFP Photo/Martin Bureau)" title

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Pills to prevent HIV raise many questions: studies

"A pharmacist shows anti-retroviral drugs in 2006 at the Mildmay Centre in Seguku, near Kampala, Uganda. Various trials examining the use of anti-retroviral drugs in healthy heterosexuals as a way to prevent HIV have shown drastically different results, research showed Wednesday. (AFP Photo/Stuart Price)" title

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Staying Motivated

My Weight Loss Journey Who hasn’t had the experience of getting ready for a party, date or just going to work only to discover when putting on those clothes you had in mind to wear, they just won’t fit comfortably anymore! Well that happened to me recently, in fact that is happening to me… By: C4rmen in  Health and Fitness  >  Weight Loss   Mar 07, 2012   2   Likes: 2



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Fiber Intake Linked to a Longer Life and Healthier Arteries

The importance of adequate fiber intake as a part of a healthy diet has been driven home by two studies published this month in the American Journal of Clinical Nutrition.  One study proves that fiber helps you live longer, and the other shows that consistent fiber consumption over many years is linked to healthier arteries.

The first study involved 452,717 European men and women followed for 12 years, comparing fiber intake to causes of death.  Fiber was inversely associated with mortality risk.  For each 10 gram increase in dietary fiber intake there was a 10 percent risk reduction in death from all causes.  Fiber offered a 39 percent risk reduction for digestion-related mortality, a 23 percent risk reduction for respiratory-related mortality, and a 15 percent risk reduction for inflammatory disease mortality. 

A second study of 373 people evaluated their fiber intake over a 24 year period, from ages 13 – 36.  At age 36 the participants had their arteries evaluated for stiffness using ultrasonography.  Those with stiffer carotid arteries had lower intakes of fiber over the 24 years.  This study speaks to the importance of a good diet throughout life and makes the point that a low fiber diet results in measurable adverse decline in the health of arteries at the relatively young age of 36.

Fiber is one of the most lacking components in the Western diet, one of several key nutritional substances that when lacking sets the stage for early disease and a shorter life. 

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