Killer disease in Cambodia stumps experts

"A doctor checks a child at Kantha Bopha children's hospital in Phnom Penh. Medical experts are scrambling to respond to what the Cambodian health ministry and World Health Organization have labelled an "undiagnosed syndrome" that has claimed the lives of at least 56 boys and girls, mostly toddlers, since April" title

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Finding a Quality Eye Wrinkle Cream

July 5, 2012 by admin

While many people always tend to notice the aging of their skin in the form of wrinkles that form around the nose, cheeks or mouth area, it is not always as obvious that the condition of your eyes and the skin that surrounds them can be much more telling when it comes to the visibility of aging in the face. Many people also don’t realize that you should begin paying special attention to the skin around your eyes long before you ever see wrinkles start to form if you want to effectively slow the effects of aging on your face. Choosing the best eye wrinkle cream that you can find will often help to combat these signs of aging.

Did you know that the skin around and under your eyes doesn’t produce any oil? While it may seem that the rest of your face produces enough oil to go around, you should know that this inherently leaves the skin around your eyes very susceptible to early signs of aging.

Also, neglecting your general level of health is most visibly reflected in the skin around your eyes in the form of puffy eyes or dark circles. Finding the best eye wrinkle cream for your symptoms and skin type will put you well on your way to taking good care of your facial skin.

There are many anti wrinkle creams on the market today, but not all of them can effectively treat the wrinkles that form around your eyes. For the most visible results, choose the best eye wrinkle cream that you can afford, because these creams are specially designed to treat the skin found around the eyes. One of the most effective products of this kind is known as Relastin Eye Silk. Picked by Allure magazine as an Editor’s Choice product, this product utilizes a unique formula of zinc firming compounds that helps your own skin cells form elastin, a skin protein that prevents sagging and lines.

Another one of the best eye wrinkle cream products on the market today is called RevaleSkin Replenishing Eye Therapy.

This product is designed specifically to take care of the delicate skin around your eyes using a CoffeeBerry extract, which serves as a very powerful antioxidant. Working very quickly, this product will help to bring life and youth to the skin of your face, and will usually eliminate the need to use a lot of concealer under your eyes to hide the dark, puffy skin.

Anti Aging

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Natural Ways to Boost Your Calorie Burn And Speed Weight Loss

Cheat Your Ab Fat Away How To Cheat Nature To Get A Flat Stomach Once you understand how the four components of ab fat elimination work, diet, sleeping, drinking, and exercise and once you have them all working for you there are ways that you can cheat mother nature and meet your goals faster.  Now… By: Paul Tooley in  Health and Fitness  >  Weight Loss   Mar 10, 2011   0   Likes: 0

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Exercise for the Home

Why Exercise All of you have different reasons why to exercise. For some of you its just to get lean body for the summer, some of you are looking to get six pack abs, or ripped muscular body. Many people are looking for health benefits, in my opinion the best reason to… By: Marko Mustac in  Health and Fitness  >  Exercise   Jun 21, 2012   4   Likes: 4

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-Exclusive French Chef Dinner- At Scarlett Wine Bar and Restaurant

"Exclusive French Chef Dinner" At Scarlett Wine Bar & RestaurantShare: Tweet04
Jul
2012"Exclusive French Chef Dinner" At Scarlett Wine Bar & Restaurant Thursday 5th, Friday 6th & Saturday 7th of July 2012 - Treat yourself with a gourmet culinary experience by guest French Chef Sylvain Royer at Scarlett Wine Bar and Restaurant.

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Powertec, Inc. Announces their Title Sponsorship of the 2012 Model and Fitness World Finale in Hollywood, California

Powertec, Inc. Announces their Title Sponsorship of the 2012 Model & Fitness World Finale in Hollywood, CaliforniaShare: Tweet03
Jul
2012Powertec, Inc. Announces their Title Sponsorship of the 2012 Model & Fitness World Finale in Hollywood, CaliforniaPowertec Inc., is pleased to announce their Title Sponsorship of the first annual Model & Fitness (M&F) World Finale pageant on September 14-15, 2012.

Los Angeles-Long Beach, CA (1888PressRelease) July 03, 2012 - Powertec Inc., the World's Best Selling Plate-Loaded Home Gym Brand, will be the Title Sponsor of the first annual Model & Fitness (M&F) World Finale pageant on September 14-15, 2012 at the rooftop pool at Drai's Lounge, part of the world-renowned W Hotel in Hollywood.

This two-day World Finale event is the capstone to this year's Model & Fitness regional competitions in Remini, Italy; Monte Carlo, Monaco; and Milan, Italy. M&F federation is an elite competition circuit and natural fitness federation within the Fitness Industry. Dr. Marco Zanetti, founder of M&F, has extensive experience and network in the fitness world, producing national and continental fitness and bodybuilding competitions for the last 7 years. Known for providing the world's fitness models and competitors a high level of pageantry in the world's most exotic and prestigious locations, M&F strives to attract the world's best -looking fit models in a competition format, as Miss Universe is to the Beauty world, with high caliber categories that are of interest to those in the general public attracted to the physical ideal.

Powertec Spokesperson and M&F USA President Natalie Minh says, "Powertec Fitness, the industry leader in Plate Loaded Home Gyms, is pleased to partner with the Model & Fitness organization, bringing together healthy, commercial looking talents in a competition environment coupled with a retreat-styled fitness weekend in Hollywood, CA. No other model competition circuit in the world brings the production value, locations, talent, scouts, and industry decision makers into one venue how M&F events aspires to.

As a commercial client regularly seeking top fitness and swimsuit models for hire, we understand the value in supporting such events: they are casting calls and market makers rolled into one. We hope to lead and inspire other corporations to join us in this goal of linking the pageant competitors to paying jobs."

The two-day competition and three-day weekend will be hosted at the following venues:



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The Semi-Permanent Health Fix Sorting out Britain's Most Embarrassing Health Problem

provides a semi-permanent and non-invasive solution.

(1888PressRelease) July 03, 2012 - Semi-permanent beauty treatments such as botox, fillers and chemical peels have increased in popularity in recent years in the UK. The British Association of Aesthetics Plastic Surgeons recorded a 6.7% rise in the number of facial rejuvenation procedures

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Kiwaii Announces Authentic New Label Design

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2012Kiwaii announces redesigned bottle label, now in stores.

(1888PressRelease) July 03, 2012 - Hellertown, PA - Kiwaii True New Zealand Spring Water wants everyone to know exactly where their pure natural spring water comes from. That's why Premium Healthy Spring Water Inc. (PHSW) announced today that the company has modified the design of the Kiwaii brand bottle. The new labels started hitting store shelves in June.

Kiwaii formerly had a picture of a New Zealand waterfall on the label. Kiwaii's clear square bottle now contains a picture of the Blue Spring, the actual source of the water, in the background.

"How many other brands show you exactly where their water comes from?" says Lou Savant, PHSW CEO. "The Blue Spring in New Zealand is a unique water source. It is very pristine and beautiful. Putting a picture of the Blue Spring on the label is honest and consistent with our company values. Kiwaii is 100% natural and nothing is done to alter the natural properties of the water. Kiwaii tastes like water is supposed to taste - as clean and refreshing as it looks."

The company named the brand "Kiwaii True Spring Water" to make a bold statement.

"Consumers have the right to know the complete truth about products they consume - including where it comes from, how it's made and what's in it," says Savant. The company has always made Kiwaii's full water analysis available to consumers through their website, kiwaii.com. "We tell people exactly where Kiwaii comes from and what is in it."

About Kiwaii 100% True New Zealand Spring Water

Kiwaii, pronounced (key-why-ee), is a combination of the words "Kiwi" and "Wai". "Kiwi" is the nickname of the New Zealand people and "Wai" is the New Zealand native Maori word for water.

Kiwaii originates from the "Blue Spring", an abundant artesian spring on the North Island of New Zealand. New Zealand is well known for its diverse natural beauty, pristine ecosystems and strong protection of natural resources. Only a small fraction of the spring's daily 13 million gallon output is permitted for bottling. Eco-conscious consumers can be confident Kiwaii's bottling operation has zero downstream impact on the local environment, and the spring is indefinitely renewable and sustainable.
Kiwaii is bottled in a state-of-the-art, certified organic and kosher facility. The natural properties and purity of the Blue Spring give Kiwaii a smooth, clean taste unlike any other water.

Kiwaii is sold in more than 1,500 grocery and natural food stores in the United States plus three Caribbean islands, Japan and New Zealand. For more information call 1-877-4KIWAII or visit kiwaii.com.

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Kiwaii to sponsor San Francisco Avon Walk for Breast Cancer

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2012Kiwaii 100% True New Zealand Spring Water to sponsor Avon Walk, San Francisco.

(1888PressRelease) July 04, 2012 - Kiwaii 100% True New Zealand Spring Water is pleased to announce that it is a proud sponsor of the Avon Walk for Breast Cancer, July 7-8 in San Francisco.

The Avon Walk covers nine cities across the country, covering 39.3 miles over a weekend and raises significant awareness and funds to fight breast cancer. Since 2003, efforts of 150,000 Avon Walk participants, more than $440 million has been raised and donated to breast cancer programs.

"At Kiwaii, our focus never strays from the health and well-being of our customers," President and CEO Lou Savant said. "We're extremely proud to be able to help a cause as vital as the Avon Walk. With every step along their 39-mile journey, the Avon walkers are doing their part to make a difference for people living with breast cancer. We're proud to do our part to support them."

Kiwaii's artesian spring water is sourced from the pristine Blue Spring, in Putaruru, New Zealand. Kiwaii is bottled in a state-of-the-art facility under certified organic and kosher conditions - validation of the care and purity that goes into every bottle, as well as the company's commitment to providing consumers with the healthiest, most natural water on the market.

Kiwaii is available in several northern California retailers, including Whole Foods Markets, Andronico's Markets, Mollie Stone's Markets, Draegers Market, Nugget Markets and New Leaf Community Markets.

About Kiwaii 100% True New Zealand Spring Water
Kiwaii 100% True New Zealand Spring Water originates from a single trusted source-the magnificent Blue Spring in Putaruru, Waikato, New Zealand. Kiwaii is bottled in a state-of-the-art, certified organic and kosher facility in Waikato, New Zealand. The natural properties and purity of the Blue Spring give Kiwaii a smooth, clean taste unlike any other water. For more information call 1-877-4KIWAII or visit kiwaii.com.

Corporate Contact
Louis Savant
Premium Healthy Spring Water, Inc.
1866 Leithsville Road #310
Hellertown, PA 18055
1-877-4KIWAII (454-9244)
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Lactoferrin Helps Bones, Periodontal Problems and Weight Loss

Lactoferrin is one of the most potent immune modulating compounds known.  It should be naturally produced in your saliva, and has been proven to be lacking in individuals who are overweight or who have insulin resistance.  The lack of lactoferrin in your saliva enables germ imbalances that promote the wear and tear of your jaw bone, leading to periodontal problems.  This leads to a triad of overlapping problems: general bone loss, dental problems, and difficulty losing weight.  Several new studies explain how bovine lactoferrin can help.

As I explained in yesterday’s article on oregano oil, people who are overweight and struggle with weight loss typically have too much toxic LPS coming from the germ gangs that line their digestive system.  When that LPS reenters the circulation one of the adverse things it does is travel to your bones wherein it provokes the inflammatory release of TNFa Cytokine involved with systemic inflammation and regulation of immune cells. It is able to induce cell death, and inhibits tumorigenesis and viral replication. When dysfunctional it is associated with a number of disease processes. within bone, in turn inducing bone loss.  One of the new studies documents the precise mechanism showing how bovine lactoferrin can help your bones in general, showing how it blocked the LPS activation of inflammation in various ways, including the suppression of TNFa Cytokine involved with systemic inflammation and regulation of immune cells. It is able to induce cell death, and inhibits tumorigenesis and viral replication. When dysfunctional it is associated with a number of disease processes. and NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. .  The authors concluded, “Bovine lactoferrin could be a potent therapeutic agent for inflammatory diseases associated with bone destruction, such as periodontitis and rheumatoid arthritis.”

The second study was an observational clinical trial wherein bovine lactoferrin was rubbed into the gums of patients with periodontitis.  Fluid extracted from the inflamed areas showed a lowering of inflammatory signals.  Patients experienced a noticeable reduction in edema, bleeding, pocket depth, gingival and plaque index.  The authors concluded, “Even if other clinical trials are required, these results provide strong evidence for a role of bovine lactoferrin in curing periodontitis, thus extending the therapeutic potential of this multifunctional natural protein.”

While periodontal problems can occur in anyone, they are common in people who are overweight due to the reduction in natural lactoferrin from the stress of excess body fat.  I previously reported on an eight week clinical trial in overweight individuals demonstrating that 300 mg per day of bovine lactoferrin helped them lose their abdominal fat (the most inflammatory kind of fat). 

Whether you rub it directly into your gums or take it orally, bovine lactoferrin is one nutrient that can help three typically co-occurring issues:  bone wear and tear, periodontal problems, and sluggish metabolism.  On top of that, bovine lactoferrin is one of the best studied natural immune support compounds available.

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Obesity, larger waist size associated with better outcomes in heart failure patients

ScienceDaily (July 3, 2012) — A slim waist and normal weight are usually associated with better health outcomes, but that's not always the case with heart failure patients, according to a new UCLA study.

See Also:Health & MedicineObesityHeart DiseaseCholesterolStroke PreventionDiseases and ConditionsDiet and Weight LossReferenceArtificial heartIschaemic heart diseaseRheumatic feverHypertension

Researchers found that in both men and women with advanced heart failure, obesity -- as indicated by a high body mass index (BMI) -- and a higher waist circumference were factors that put them at significantly less risk for adverse outcomes.

The study findings are published in the July 1 online issue of the American Journal of Cardiology.

Heart failure affects 5.8 million people, including 2.5 million women. Approximately one-half to two-thirds of heart failure patients are overweight or obese.

Women and men are known to have differences in body composition and body-fat distribution, and this study is one of the first to specifically assess the impact of BMI and waist circumference on women and compare it with men.

The findings also offer further insight into an observed phenomenon in chronic heart failure known as the "obesity paradox": Obesity is a known risk factor for developing heart disease and heart failure, but once heart failure has manifested, being overweight may provide some protective benefits.

"The study provides us with more insight about how both genders of heart failure patients may be impacted by the obesity paradox," said senior author Dr. Tamara Horwich, an assistant professor of cardiology at the David Geffen School of Medicine at UCLA. "Heart failure may prove to be one of the few health conditions where extra weight may prove to be protective."

For the study, researchers analyzed data on advanced heart failure patients treated at UCLA Medical Center from 1983 to 2011. The team assessed 2,718 patients who had their BMI measured at the beginning of heart failure treatment and 469 patients who had their waist circumference measured at the beginning of treatment.

Using standardized measures, the researchers identified men or women as having a high BMI if they were greater or equal to 25 kg/m² -- this included both overweight patients (25 to 29.9 kg/m²) and obese patients (30 kg/m² or greater).

For men, a high waist circumference was considered 40 inches (102 cm) or greater, and for women, 37 inches (88 cm) or greater. This assessment also included patients who were either overweight or obese.

At the two-year follow-up, researchers used statistical analysis and found that in men, a high waist circumference and high BMI were associated with event-free survival from adverse outcomes like death, the need for a heart transplant, or the need for ventricular assist device placement.

Women with a higher BMI also had better outcomes than their normal-weight counterparts, and women with a high waist circumference also trended toward improved outcomes.

Both men and women with a normal BMI and waist circumference were at a substantially higher risk for these adverse outcomes. In fact, a normal BMI was associated with significantly worse outcomes -- a 34 percent higher risk in men and a 38 percent higher risk in women -- than a high BMI.

Normal waist circumference was also associated with an increased risk of adverse outcomes in both genders, with men's risk doubling and women's risk tripling.

"We knew that obesity might provide a protective benefit for heart failure patients, but we didn't know whether this obesity paradox applied specifically to women with heart failure, as well as men -- and it does," Horwich said.

BMI measurement has been used for years as a surrogate measure of body fat. Since it measures all mass -- including lean muscle, which weighs more than fat -- the measurement may not be specific for total body fat. Waist circumference is a newer addition that may provide a more direct connection to body fat, since it measures the fat accumulated around the belly.

"The study also demonstrates how BMI and waist circumference can be used together to provide a more accurate measure of fat in the body to help determine obesity and assess risk," said the study's first author, Adrienne L. Clark, a resident in the department of medicine at the Geffen School of Medicine.

According to Horwich, no one knows exactly why the obesity paradox exists for heart failure patients, but there are several possible explanations.

Being underweight is traditionally associated with a poorer prognosis in heart failure patients. Obesity may be at the other end of the spectrum, and patients may thereby benefit from increased muscle mass, as well as metabolic reserves in the form of fatty tissue. In addition, increased levels of serum lipoproteins that are associated with increased body fat may play an anti-inflammatory role, neutralizing circulating toxins and inflammation-related proteins.

Obese patients also present at an earlier stage of heart failure due to increased symptoms and functional impairment caused by excess body weight, so they may be getting help sooner, which also could improve outcomes, the researchers said.

The next steps in research will include larger studies with longer follow-up times, as well as a closer look at the physiology behind the obesity paradox.

The study was funded by the National Heart, Lung and Blood Institute, part of the National Institutes of Health (grant 1K23HL085097).

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How cellular pathways converge to regulate food intake and body weight

ScienceDaily (July 3, 2012) — In the complex chain of molecular events that underlie eating behaviors and body weight, the AMP-activated protein kinase (AMPK) enzyme has proven to be a critical link.

See Also:Health & MedicineObesityDiet and Weight LossFitnessDiseases and ConditionsColon CancerCancerReferenceAppetiteSkeletal muscleBlood sugarInsulin-like growth factor

Now, researchers at Beth Israel Deaconess Medical Center (BIDMC) have identified the mechanism responsible for inhibition of AMPK activity in the hypothalamus, a discovery that not only provides a deeper understanding of energy balance but also reveals a critical integration point where multiple signaling pathways, including PI3K-AKT and mTOR converge.

Described in the July 3 issue of Cell Metabolism, the findings could yield new opportunities for the development of treatments for both metabolic diseases and cancer.

"AMPK is an evolutionarily conserved 'fuel gauge,'" says senior author Barbara Kahn, MD, a scientist in the Division of Endocrinology, Diabetes and Metabolism at BIDMC and the George Richards Minot Professor of Medicine at Harvard Medical School. Activated when cellular energy supplies are low, AMPK also functions at the whole body level to regulate metabolism and energy balance.

The Kahn laboratory was the first to describe AMPK's critical role in mediating the actions of leptin, the hormone produced by fat cells that serves as a master regulator of neuroendocrine, metabolic, vascular, sympathetic and immune function. In 2002, Kahn demonstrated that AMPK is activated by leptin in skeletal muscle, thereby enabling the hormone to metabolize fatty acids. Subsequently, in 2004, her laboratory discovered that an opposing scenario takes place in the brain's hypothalamus, where AMPK is inhibited by leptin.

"Having determined that leptin's effects on food intake and body weight depend on the inhibition of AMPK in the hypothalamus, we wanted to determine the signaling events that were responsible for this effect," she explains.

The PI3K-AKT, mTOR-p70S6 kinase and AMPK pathways play distinct and critical roles in metabolic regulation, and each pathway is necessary for leptin's anorexigenic effects in the hypothalamus, which inhibit food intake. Through a series of experiments led by first author Yossi Dagon, PhD, a postdoctoral fellow in the Kahn lab, the scientific team showed that these pathways converge in an integrated phosphorylation cascade to mediate leptin action on the hypothalamus.

"Our findings identify a novel serine phosphorylation site on the AMPK alpha 2 catalytic subunit that mediates leptin's inhibitory effects and is critical for leptin action on food intake and body weight, and further show that ribosomal p70S6 kinase is an inhibitory AMPK kinase," says Kahn. 'These discoveries unify what were thought to be multiple parallel pathways affecting leptin action including PI3 kinase and AKT into a coordinated phosphorylation cascade."

Adds study coauthor Lewis Cantley, PhD, Director of BIDMC's Cancer Center and a leader in the field of cancer metabolism, "Since PI3K, AKT, mTOR and p70S6K have all been shown to be important in cancer biology, this integration of these pathways may be important for cancer and other human diseases and could lead to improved therapeutic approaches."

Obesity has reached epidemic proportions worldwide and increases the risk for developing diabetes, cardiovascular disease and early mortality. "Maintaining normal body weight requires tight control of energy homeostasis, which necessitates a constant flow of metabolic input to the hypothalamus in the form of nutrients and hormones," says Kahn. "Our new results have broad biologic implications, since mTOR-p70S6 kinase and AMPK have multiple, fundamental and generally opposing cellular effects that regulate metabolism, cell growth and development."

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